口腔黏膜病患者血浆中炎症细胞因子的表达及意义

发布时间：2018-10-11 10:09

【摘要】：目的探讨口腔黏膜病患者血浆炎症细胞因子的表达及意义。方法应用酶联免疫吸附实验(ELISA)双抗体夹心法检测156例口腔黏膜病患者及40例健康人血浆中肿瘤坏死因子(TNF)-α、转化生长因子(TGF)-β,白细胞介素(IL)-1β及IL-6的含量,统计分析血浆中炎症细胞因子水平与口腔黏膜病的发病关系。结果口腔黏膜病患者血浆中炎症细胞因子TNF-α、TGF-β、IL-1β及IL-6的含量总体水平显著高于健康对照组(P0.01)。此外,口腔黏膜病不同型细胞因子表达水平差异有统计学意义(P0.05)。结论口腔黏膜病患者血浆中炎症细胞因子表达水平与疾病的发生发展密切相关。亦可用于黏膜病分型的诊断依据。临床上可通过阻断炎症细胞因子的生物学效应。改善或减轻口腔黏膜病的病程,为口腔黏膜病生物治疗开辟一新途径。
[Abstract]:Objective to investigate the expression and significance of plasma inflammatory cytokines in patients with oral mucosal disease. Methods the levels of tumor necrosis factor (TNF)-伪, transforming growth factor (TGF)-尾, interleukin (IL) (IL)-1 尾 and IL-6 in plasma of 156 patients with oral mucosal disease and 40 healthy controls were detected by enzyme linked immunosorbent assay (Elisa) with (ELISA) double antibody sandwich method. The relationship between plasma inflammatory cytokines and oral mucosal disease was statistically analyzed. Results the plasma levels of TNF- 伪, TGF- 尾, IL-1 尾 and IL-6 in patients with oral mucosal disease were significantly higher than those in healthy controls (P0.01). In addition, the expression level of different types of cytokines in oral mucosal disease was significantly different (P0.05). Conclusion the expression of inflammatory cytokines in the plasma of patients with oral mucosal disease is closely related to the occurrence and development of the disease. It can also be used for the diagnosis of mucosal disease classification. Clinically, the biological effects of inflammatory cytokines can be blocked. To improve or reduce the course of oral mucosal disease, open up a new way for oral mucosal disease biotherapy.
【作者单位】：吉林大学第一医院口腔科;吉林大学第一医院透析中心;
【分类号】：R781.5

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