去抗原猪松质骨修复犬颌骨缺损的影像学分析

发布时间：2018-10-19 08:16

【摘要】：目前临床应用的异种骨多来源于牛,近年来许多学者对猪骨的临床应用进行了大量的探索。因此,本研究利用去抗原猪松质骨修复狗下颌骨缺损,并进行影像学评价,为后期利用组织工程修复颌骨缺损提供新的思路。本研究通过对4只中国杂种犬施行手术,构建了双侧下颌骨骨缺损动物模型,然后采取同体双侧对照原则,随机选取一侧用犬自体骨修复(设为对照组),对侧缺损处用去抗原猪松质骨修复(设为实验组),以钛板钛钉分别予以固定,于术后第12周、第24周进行锥形束电子计算机断层扫描(CBCT)、电子计算机断层扫描(CT)和单光子发射计算机断层成像术(SPECT)检查,以SPECT与CT进行图像异机融合。研究结果显示,去抗原猪松质骨改建速度虽然较自体骨为慢,但仍可作为支架材料修复颌骨缺损。通过以上研究,本文结果或可为临床修复大面积颌骨缺损所需材料提供一种新的选择。
[Abstract]:At present, most of the xenograft used in clinic come from cattle. In recent years, many scholars have made a lot of exploration on the clinical application of pig bone. Therefore, in this study, antigen-free porcine cancellous bone was used to repair the mandibular defect in dogs, and the imaging evaluation was carried out to provide a new idea for the later use of tissue engineering to repair the mandibular defect. In this study, four Chinese mongrel dogs were operated on to construct bilateral mandibular defect animal model, and then adopt the principle of the same body bilateral control. One side was repaired with autologous bone (as control group), the other side was repaired with antigen-free porcine cancellous bone (experimental group), and fixed with titanium plate nail respectively at the 12th week after operation. Cone-beam computerized tomography (CBCT),) and single photon emission computed tomography (SPECT) were performed in the first 24 weeks. SPECT and CT were used for image fusion. The results showed that the remodeling rate of antigen-free porcine cancellous bone was slower than that of autogenous bone, but it could still be used as scaffold material to repair jaw defect. The results may provide a new choice for clinical repair of large-area maxillary defects.
【作者单位】：暨南大学附属第一医院口腔医疗中心;东莞市人民医院口腔科;
【基金】：广东省医学科研基金资助项目(A2014384) 中央高校基本科研业务费专项资金资助项目(21615482)
【分类号】：R782.4

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