曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓的疗效及安全性观察

发布时间：2018-10-20 13:40

【摘要】：目的:观察曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓(EOLP)的疗效及安全性。方法:选择62例经临床确诊的EOLP患者,随机分为2组。实验组29例采用局涂曲安奈德口腔软膏、口服硫酸羟氯喹、口含西吡氯铵含片,对照组33例采用口服硫酸羟氯喹、口含西吡氯铵含片治疗。分别于初诊、第2、4周记录患者病损面积和疼痛程度的变化,并观察初诊和4周后的安全性指标。结果:实验组在2周能加速口腔扁平苔藓的充血糜烂面的愈合(P0.05),降低患者的疼痛指数(P0.05),但4周后与对照组无统计学差异(P0.05)。实验组4例唾液真菌感染阳性(P0.05),其他安全指标与对照组无统计学差异(P0.05)。结论:曲安奈德口腔软膏配合硫酸氢喹、西吡氯铵治疗EOLP,具有良好的疗效和安全性,但要防范局部真菌感染。
[Abstract]:Objective: to observe the efficacy and safety of triamcinolone acetonide oral ointment in the treatment of congestive oral lichen planus (EOLP). Methods: 62 patients with EOLP were randomly divided into two groups. The experimental group (29 cases) were treated with oral ointment of triamcinolone acetonide, oral hydroxychloroquine sulfate and citripiramine buccal tablet, while 33 cases of control group were treated with oral hydroxychloroquine sulfate and oral buccal tablet containing citric chloride. The area of lesion and the degree of pain were recorded at the first visit and the second week, and the safety indexes were observed after the first visit and 4 weeks. Results: the experimental group could accelerate the healing of congestive erosive surface of oral lichen planus in 2 weeks (P0.05) and decrease the pain index (P0.05), but there was no significant difference between the experimental group and the control group after 4 weeks (P0.05). Four cases of salivary fungal infection were positive in the experimental group (P0.05), and no significant difference was found between the other safety indexes and the control group (P0.05). Conclusion: triamcinolone acetonide oral ointment combined with hydroquine sulfate and cepiramide has good efficacy and safety in the treatment of EOLP, but local fungal infection should be prevented.
【作者单位】：南京医科大学口腔疾病研究江苏省重点实验室南京医科大学附属口腔医院黏膜科;
【基金】：江苏高校优势学科建设工程资助项目(编号:2014-37)
【分类号】：R781.5

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