矿化胶原与镁钙合金的复合材料用于犬拔牙位点保存的实验研究
发布时间：2018-10-20 18:53
【摘要】：目的研究矿化胶原复合镁钙合金用于犬拔牙位点保存的可行性。方法拔除8只杂种犬下颌双侧第4前磨牙,共32个拔牙窝(近中和远中牙槽窝各16个),随机分为A、B两组。A组植入矿化胶原复合镁钙合金材料,B组仅植入矿化胶原材料,于术后12,24周处死实验犬,制备组织标本,通过大体观察、CBCT、肝肾组织学切片观察以及X射线显微镜检测评价拔牙窝愈合情况及肝肾组织的损伤情况。结果两组材料在拔牙窝愈合过程中,逐渐被降解吸收,新生骨组织不断形成。术后12周,实验A组的相对骨密度值以及新生骨组织数量均多于B组,差异有统计学意义(P0.05)。术后24周,A、B两组的新生骨组织数量逐渐增多,两组相对骨密度值差异不显著(P0.05)。结论矿化胶原与镁钙合金的复合材料可用于犬拔牙位点的保存,可促进新骨再生,减缓牙槽嵴的吸收。
[Abstract]:Objective to study the feasibility of mineralized collagen combined with magnesium calcium alloy for preservation of extraction sites in dogs. Methods eight mongrel dogs were randomly divided into two groups: group A implanted mineralized collagen combined with magnesium calcium alloy, group B only mineralized collagen, and group B implanted only mineralized collagen, and the mandibular fourth premolars were extracted and 32 teeth were extracted (16 in proximal and distal alveolar fossa respectively), and were randomly divided into two groups: group A was implanted with mineralized collagen and magnesium-calcium alloy, and group B only implanted mineralized collagen. 24 weeks after operation, the dogs were killed and tissue specimens were prepared. The healing of tooth extraction fossa and the injury of liver and kidney were evaluated by gross observation, histological observation of CBCT, liver and kidney and X-ray microscope. Results during the healing process, the two groups were gradually degraded and absorbed, and new bone tissue was formed. At 12 weeks after operation, the relative bone density and the number of new bone tissue in experimental group A were higher than those in group B, the difference was statistically significant (P0.05). 24 weeks after operation, the number of new bone tissue increased gradually in group A and B, and there was no significant difference in relative bone density between the two groups (P0.05). Conclusion the composite of mineralized collagen and magnesium calcium alloy can be used to preserve the extraction site of canine tooth, promote the regeneration of new bone and slow down the absorption of alveolar ridge.
【作者单位】： 锦州医科大学附属第二医院口腔修复科;北京联合大学机器人学院;
【基金】：辽宁省科学技术基金项目(2015020689)
【分类号】：R782.11
，
本文编号：2284079
[Abstract]:Objective to study the feasibility of mineralized collagen combined with magnesium calcium alloy for preservation of extraction sites in dogs. Methods eight mongrel dogs were randomly divided into two groups: group A implanted mineralized collagen combined with magnesium calcium alloy, group B only mineralized collagen, and group B implanted only mineralized collagen, and the mandibular fourth premolars were extracted and 32 teeth were extracted (16 in proximal and distal alveolar fossa respectively), and were randomly divided into two groups: group A was implanted with mineralized collagen and magnesium-calcium alloy, and group B only implanted mineralized collagen. 24 weeks after operation, the dogs were killed and tissue specimens were prepared. The healing of tooth extraction fossa and the injury of liver and kidney were evaluated by gross observation, histological observation of CBCT, liver and kidney and X-ray microscope. Results during the healing process, the two groups were gradually degraded and absorbed, and new bone tissue was formed. At 12 weeks after operation, the relative bone density and the number of new bone tissue in experimental group A were higher than those in group B, the difference was statistically significant (P0.05). 24 weeks after operation, the number of new bone tissue increased gradually in group A and B, and there was no significant difference in relative bone density between the two groups (P0.05). Conclusion the composite of mineralized collagen and magnesium calcium alloy can be used to preserve the extraction site of canine tooth, promote the regeneration of new bone and slow down the absorption of alveolar ridge.
【作者单位】： 锦州医科大学附属第二医院口腔修复科;北京联合大学机器人学院;
【基金】：辽宁省科学技术基金项目(2015020689)
【分类号】：R782.11
，
本文编号：2284079
本文链接：https://www.wllwen.com/yixuelunwen/kouq/2284079.html
最近更新
教材专著
