脂肪干细胞生物学特性及在口腔再生医学中的应用

发布时间：2018-11-09 13:44

【摘要】：背景:相比较于其他组织来源的干细胞,脂肪干细胞不仅来源广泛,获取方便,而且有强大的扩增和分化潜能,这些特点使其在口腔再生医学中有着广阔的应用前景。目的:总结脂肪干细胞的生物学特点及其在口腔再生医学中的研究进展。方法:以"脂肪干细胞,口腔组织再生,骨组织工程;牙周再生;骨缺损;adipose-derived stem cells,oral tissue regeneration,bone tissue engineering,periodontal tissue regeneration,bone defects"为检索词,应用计算机检索Pub Med、CNKI、万方数据库2000至2016年的相关文献。结果与结论:在体外牙周组织再生研究中,脂肪干细胞可以促进骨组织再生、成纤维组织再生、血管组织再生及提高牙周创面愈合能力。在口腔颅颌面骨再生研究中,脂肪干细胞作为种子细胞,可成功修复种植术前的牙槽骨缺损及外伤和肿瘤术后的大面积骨缺失。脂肪干细胞移植后的免疫原性和安全性等问题还需要进一步研究。
[Abstract]:Background: compared with stem cells derived from other tissues, adipose stem cells not only have a wide range of sources, easy to obtain, but also have strong amplification and differentiation potential. These characteristics make them have a broad application prospect in oral regenerative medicine. Objective: to summarize the biological characteristics of adipose stem cells and their advances in oral regenerative medicine. Methods: adipose stem cells, oral tissue regeneration, bone tissue engineering, periodontal regeneration, bone defect; Adipose-derived stem cells,oral tissue regeneration,bone tissue engineering,periodontal tissue regeneration,bone defects "was used to search the relevant documents of Pub Med,CNKI, Wanfang database from 2000 to 2016." Results & conclusion: in the study of periodontal tissue regeneration in vitro, adipose stem cells can promote bone regeneration, fibroblast regeneration, vascular regeneration and improve the healing ability of periodontal wound. In the study of craniomaxillofacial bone regeneration, adipose stem cells, as seed cells, can successfully repair alveolar bone defects before implantation and large areas of bone defects after trauma and tumor. The immunogenicity and safety of adipose stem cells after transplantation need further study.
【作者单位】：同济大学口腔医学院口腔颌面外科教研室上海牙组织修复与再建工程技术研究中心;同济大学附属东方医院口腔科;
【基金】：上海市科技委员会基金(14411963500);名称:新型淫羊藿苷缓释支架材料修复种植体周围骨缺损的实验研究上海市卫计委青年项目(20154Y0200);名称:富血小板纤维蛋白(PRF)在下颌第三磨牙拔除后第二磨牙远中牙槽嵴保存的应用~~
【分类号】：R781

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