复发性阿弗他溃疡患者焦虑与唾液皮质醇和脱氢表雄酮水平的相关性研究
发布时间：2018-12-08 21:10
【摘要】：目的:分析复发性阿弗他溃疡(RAU)发病与焦虑情绪之间的关系,对比RAU患者和对照组唾液中皮质醇含量、脱氢表雄酮(DHEA)含量、皮质醇/DHEA比值,并进一步探讨RAU患者焦虑情况与唾液皮质醇水平、DHEA水平以及皮质醇/DHEA比值的相关性,选择出能够在临床上评估焦虑与RAU关系的重要指标。方法:选取30例于佳木斯大学附属口腔医院牙周黏膜病科就诊并诊断为轻型RAU的患者作为实验组。另外纳入同期在佳木斯大学附属口腔医院体检科检查显示口腔黏膜健康的30名健康人为对照组。在上午8-10点之间对每个受试者进行唾液样本的收集,并采用医院焦虑抑郁量表焦虑分表(HAD-A)分别评定每个受试对象的焦虑水平,收集的唾液样本置于-80℃的冰箱中存放,实验前将其置于室温融化,离心后去掉沉渣,采用酶联免疫吸附法(ELISA)对两组受试者唾液中的皮质醇水平和DHEA水平进行测定,并计算皮质醇/DHEA的比值,通过统计学比较每组对象的焦虑情况、唾液皮质醇水平、唾液DHEA水平以及唾液皮质醇/DHEA比值的差异,并分析RAU患者焦虑与唾液皮质醇、DHEA水平以及二者之间比值的相关性。结果:1统计学分析显示,RAU组焦虑得分为10.53±3.73,对照组焦虑得分为5.47±3.56,差异具有统计学意义(P0.05)。RAU组唾液皮质醇的水平是39.58±8.76ug/L,明显高于对照组的19.84±6.94 ug/L,差异具有统计学意义(P0.01)。RAU组的唾液DHEA水平为38.08±11.96 nmol/L,虽低于对照组的49.36±12.05 nmol/L,但差异并无统计学意义(P0.05)。RAU组的皮质醇/DHEA比值是1.20±0.64,显然比对照组的0.43±0.21要高,差异具有统计学意义(P0.05)。2 Pearson相关性分析发现,RAU实验组的焦虑得分与唾液皮质醇水平具有一定的相关性,且为正相关,相关系数r=0.685,P0.01。RAU组的焦虑得分与皮质醇/DHEA的比值也具有高度相关性,且为正相关,相关系数r=0.641,P0.01。结论:1 RAU的发生与焦虑情绪有关。2 RAU患者唾液皮质醇水平相对升高,唾液DHEA水平无明显变化,皮质醇/DHEA比值也相对升高。3 RAU患者焦虑水平与唾液中皮质醇水平以及皮质醇/DHEA比值有一定的相关性,临床上可以通过检测唾液中皮质醇的含量以及皮质醇/DHEA的比值来评估RAU发病与焦虑的关系。
[Abstract]:Objective: to analyze the relationship between (RAU) and anxiety in recurrent aphthous ulcer, and to compare the levels of cortisol, dehydroepiandrosterone (DHEA), cortisol / DHEA in saliva of RAU patients and controls. Furthermore, the relationship between anxiety and salivary cortisol level, DHEA level and cortisol / DHEA ratio in patients with RAU was further investigated, and an important index to evaluate the relationship between anxiety and RAU was selected. Methods: thirty patients with mild RAU were selected from periodontal mucosal disease department of Stomatology Hospital affiliated to Jiamusi University as experimental group. In addition, 30 healthy persons who were examined in the Department of physical examination of Stomatology Hospital affiliated to Jiamusi University in the same period were taken as control group. Saliva samples were collected from 8 to 10 a.m. and the anxiety level of each subject was assessed by the Hospital anxiety and Depression scale anxiety scale (HAD-A). The collected saliva samples were stored in a refrigerator at -80 鈩，
本文编号：2369004
[Abstract]:Objective: to analyze the relationship between (RAU) and anxiety in recurrent aphthous ulcer, and to compare the levels of cortisol, dehydroepiandrosterone (DHEA), cortisol / DHEA in saliva of RAU patients and controls. Furthermore, the relationship between anxiety and salivary cortisol level, DHEA level and cortisol / DHEA ratio in patients with RAU was further investigated, and an important index to evaluate the relationship between anxiety and RAU was selected. Methods: thirty patients with mild RAU were selected from periodontal mucosal disease department of Stomatology Hospital affiliated to Jiamusi University as experimental group. In addition, 30 healthy persons who were examined in the Department of physical examination of Stomatology Hospital affiliated to Jiamusi University in the same period were taken as control group. Saliva samples were collected from 8 to 10 a.m. and the anxiety level of each subject was assessed by the Hospital anxiety and Depression scale anxiety scale (HAD-A). The collected saliva samples were stored in a refrigerator at -80 鈩，
本文编号：2369004
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