“新净界漱口水”对放射性口腔黏膜炎的防治效果观察

发布时间：2019-03-01 17:57

【摘要】：目的:前瞻性随机双盲研究"新净界漱口水"对放射性口腔黏膜炎的防治效果。方法 :60例拟行放疗的口腔癌患者随机分为试验组和对照组;试验组30例,自放疗第1天起,每天使用"新净界漱口水"含漱4次,每次5 m L,含漱5 min,直至放疗结束。对照组30例使用生理盐水含漱,方法同试验组。按RTOG口腔黏膜炎分级标准评价2组患者的口腔黏膜炎严重程度,记录疼痛程度,并照相存档。3级口腔黏膜炎视为终止指标,发生者给予其他药物治疗。应用Stata 12.0软件包对数据进行统计分析。结果:2组患者的年龄、性别、放疗技术和剂量无显著差异(P0.05)。试验组首次观察到黏膜炎的发生时间较对照组晚(照射11.0次∶9.1次,P0.05),且试验组在早期出现疼痛的比例较对照组低(36.7%∶70.0%,P0.05)。另外,试验组3级口腔黏膜炎的出现时间较对照组晚(照射18.9次∶15.9次,P0.05),发生率较对照组低(63.3%∶90.0%,P0.05)。结论:"新净界漱口水"能延缓放疗所致口腔黏膜炎的发生时间,减轻患者的疼痛症状,并能减少3级口腔黏膜炎的发生率,值得临床使用。
[Abstract]:Objective: to study the efficacy of Xinjing mouthwash in the prevention and treatment of radiation oral mucositis. Methods: sixty patients with oral cancer were randomly divided into two groups: experimental group (n = 30) and control group (n = 30). Since the first day of radiotherapy, 30 patients in the test group were treated with "Xinjing mouth mouthwash" for 4 times a day, 5 mL each time, including 5 min, until the end of radiotherapy. The control group (n = 30) was treated with saline gargling with the same method as the test group. According to RTOG classification criteria of oral mucositis, the severity of oral mucositis in two groups was evaluated, pain was recorded and photographed archived. Grade 3 oral mucositis was regarded as an index of termination, and other drugs were given to patients with oral mucositis. The data were analyzed by Stata 12.0 software package. Results: there was no significant difference in age, sex, radiotherapy technique and dose between the two groups (P0.05). The onset time of mucositis in the experimental group was later than that in the control group (11.0 times: 9.1 times, P0.05), and the percentage of early pain in the experimental group was lower than that in the control group (36.7% vs 70.0%, P0.05). In addition, the occurrence time of grade 3 oral mucositis in the experimental group was later than that in the control group (18.9 times: 15.9 times, P0.05), and the incidence was lower than that in the control group (63.3% / 90.0%, P0.05). Conclusion: "Xinjing mouthwash" can delay the occurrence time of oral mucositis induced by radiotherapy, relieve the pain symptoms of patients, and reduce the incidence of grade 3 oral mucositis, which is worthy of clinical use.
【作者单位】：上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科上海市口腔医学重点实验室;
【分类号】：R781.5

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