分化抑制蛋白-1和基质金属蛋白酶2在涎腺腺样囊性癌中的表达及临床意义

发布时间：2019-03-26 12:35

【摘要】：目的探讨分化抑制蛋白-1(Id-1)和基质金属蛋白酶2(MMP-2)在涎腺腺样囊性癌(SACC)中的表达及其与肿瘤侵袭和转移的相关性。方法用免疫组织化学方法检测Id-1和MMP-2在60例SACC组织(实验组)与60例癌旁正常组织(对照组)中的表达情况,分析二者的表达与SACC浸润和侵袭的相关性。结果实验组和对照组的Id-蛋白阳性表达率分别为68.33%(41/60例)和13.33%(8/60例);MMP-2蛋白阳性表达率分别为73.33%(44/60例)和18.33%(11/60例),差异有统计学意义(P0.001)。Id-1和MMP-2的阳性表达率在有淋巴结转移者分别为83.33%,87.50%、在无淋巴结转移者分别为58.33%,63.90%;在肺转移者分别为88.24%,94.12%、在无肺转移者分别为60.47%,65.12%;在Ⅲ+Ⅳ期者分别为81.48%,88.89%、在Ⅰ+Ⅱ期者分别为57.58%,60.61%;在中/低分化者分别为85.71%,91.42%、在高分化者分别为44.00%,48.00%;在伴脉管浸润者分别为89.47%,100.00%、无脉管浸润者分别为58.54%,60.98%;且Id-1和MMP-2在上述前者的阳性表达率明显高于后者,差异有统计学意义(P0.05)。Id-1和MMP-2的阳性表达率在男性分别为66.67%,75.00%、在女性分别为70.83%,70.83%;在≥50岁者分别为73.53%,76.47%、在50岁者分别为61.54%,69.23%;在小涎腺者分别为63.64%,72.73%、在大涎腺者分别为71.05%,73.68%;且Id-1和MMP-2在上述前者和后者的阳性表达率比较差异无统计学意义(P0.05)。Id-1和MMP-2在SACC中的表达呈正相关。结论 Id-1和MMP-2的异常表达在SACC发展、浸润过程中起重要作用,联合检测Id-1和MMP-2的表达水平有可能作为监测SACC进展和转移的生物学指标。
[Abstract]:Aim to investigate the expression of inhibitor of differentiation protein-1 (Id-1) and matrix metalloproteinase-2 (MMP-2) in salivary adenoid cystic carcinoma (SACC) and their correlation with invasion and metastasis. Methods Immunohistochemistry was used to detect the expression of Id-1 and MMP-2 in 60 cases of SACC tissues (experimental group) and 60 cases of normal tissues adjacent to carcinoma (control group). The correlation between the expression of SACC and the invasion and invasion of SACC was analyzed. Results the positive expression rates of Id- protein in experimental group and control group were 68.33% (41 / 60) and 13.33% (8 / 60), respectively. The positive expression rates of MMP-2 protein were 73.33% (44 / 60) and 18.33% (11 / 60), respectively. The positive expression rates of Id-1 and MMP-2 were 83.33%, 87.50% and 58.33%, 63.90% in the patients with lymph node metastasis, and those without lymph node metastasis, respectively (P0.001). The rates of lung metastasis were 88.24%, 94.12%, 60.47%, 65.12%, 81.48%, 88.89%, 57.58%, 60.61% in stage 鈪，

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