上颌骨低度恶性肌纤维母细胞肉瘤

发布时间：2019-04-10 18:19

【摘要】：目的：低度恶性肌纤维母细胞肉瘤（LGMS，low-grademyofibroblasticsarcomas）是肌纤维母细胞恶性肿物中一种独特的间叶性肿瘤，可发生于身体多个部位，但更倾向于头颈部区域。我们分析了两例上颌骨低度恶性肌纤维母细胞肉瘤，其中一例术前活检诊断为炎性肌纤维母细胞瘤，并且复发肿瘤出现了免疫表型的改变。方法：分别对两个病例选择有代表性的蜡块，制作3微米厚切片进行免疫组织化学染色。所用的一抗为：α-SMA平滑肌肌动蛋白,MSA肌特异性蛋白,desmin结蛋白,vimentin波形蛋白,calponin钙调蛋白,h-caldesmon高分子钙调结合蛋白,fibronectin纤维连接蛋白,cytokeratin角蛋白,CD34分子,s-100蛋白,ALK间变性淋巴瘤激酶,EMA上皮膜抗原,Ki-67。本次实验采用SP三步法。结果：两病例中的瘤细胞对vimentin波形蛋白和FN纤维连接蛋白均呈阳性，对S-100蛋白，CD34分子，EMA上皮膜抗原，h-caldesmon高分子钙调结合蛋白，ALk间变性淋巴瘤激酶，calponin钙调蛋白均呈阴性。病例1中瘤细胞α-SMA平滑肌肌动蛋白阳性，desmin结蛋白阴性。病例2原发肿瘤瘤细胞α-SMA平滑肌肌动蛋白和desmin结蛋白均阳性，但复发后瘤细胞呈平滑肌肌动蛋白阳性，，desmin结蛋白阴性。结论：我们提出一个假设，即：复发后出现免疫表型改变的低度恶性肌纤维母细胞肉瘤愈后相对更差。
[Abstract]:Aim: low grade malignant myofibroblastic sarcoma (LGMS,low-grademyofibroblasticsarcomas) is a unique mesenchymal tumor of myofibroblastic malignancy. It can occur in many parts of the body, but it is more likely to be in the head and neck region. We analyzed two cases of low grade malignant myofibroblastic sarcoma of maxilla, one of which was diagnosed as inflammatory myofibroblastoma by biopsy before operation, and the recurrent tumors showed immunophenotypic changes. Methods: the representative wax blocks were selected from two cases, and 3 渭 m thick sections were made for immunohistochemical staining. The primary antibodies used were 伪-SMA smooth muscle actin, MSA muscle specific protein, desmin node protein, vimentin, calponin calmodulin, h-caldesmon macromolecule calmodulin, fibronectin, cytokeratin keratin, CD34 molecule. Sp 100 protein, ALK anaplastic lymphoma kinase, EMA epithelial membrane antigen, Ki-67. SP three-step method was used in this experiment. Results: the tumor cells in both cases were positive for vimentin and FN fibronectin. They were positive for Sal 100 protein, CD34 molecule, EMA epithelial membrane antigen, h-caldesmon high molecular calmodulin binding protein, ALk anaplastic lymphoma kinase. Calponin calmodulin was negative. In case 1, 伪-SMA smooth muscle actin was positive and desmin node protein was negative in tumor cells. In case 2, the primary tumor cells were positive for 伪-SMA smooth muscle actin and desmin node protein, but after recurrence, the tumor cells were positive for smooth muscle actin and negative for desmin node protein. Conclusion: we propose an assumption that low grade myofibroblastic sarcomas with immunophenotypic changes after recurrence are relatively worse after recovery.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R739.8

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