牙周炎与患者机体代谢综合征的相关性及中药治疗的临床效果

发布时间：2019-05-17 08:44

【摘要】：目的统计学分析牙周炎患者机体代谢综合征指标,探讨牙周炎与代谢综合征的相关性及中药治疗的临床效果。方法选取符合牙周炎诊断标准并愿意接受20 d中药治疗的患者140例为研究对象,按照牙周炎的严重程度分为轻度牙周炎组70例和中重度牙周炎组70例。同时选取符合牙周炎诊断标准的并仅接受西药治疗的患者140例,同样分为轻或中重度牙周炎组,各70例。比较4组患者血压(SBP和DBP)、血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,应用Logistic多因素回归分析探讨牙周炎与代谢综合征的相关性。观察中药方剂治疗前后牙周炎患者机体代谢综合征的变化情况,明确相关指标与牙周炎的关系。结果 4组牙周炎患者TG、HDL-C及FPG等3指标间的比较具有显著性差异(P0.05),DBP及TC间的差异无显著性;中西药治疗法在中重度牙周炎患者中的疗效差异具有显著性;中药显效的患者机体代谢综合征指标SBP、FPG、TC、TG、LDL-C均低于治疗前,HDL-C水平较治疗前高,差异有显著性(P0.05)。结论牙周炎的严重程度与患者机体代谢综合征指标间具有一定的相关性,中药治疗牙周炎的效果显著优于西药。
[Abstract]:Objective to analyze the indexes of metabolic syndrome in patients with periodontitis and to explore the correlation between periodontitis and metabolic syndrome and the clinical effect of traditional Chinese medicine (TCM). Methods 140 patients who met the diagnostic criteria of periodontitis and were willing to be treated with traditional Chinese medicine for 20 days were divided into mild periodontitis group (n = 70) and moderate to severe periodontitis group (n = 70) according to the severity of periodontitis. At the same time, 140 patients who met the diagnostic criteria of periodontitis and received only western medicine were divided into mild or moderate periodontitis group with 70 cases each. Blood pressure (SBP) and DBP), blood glucose (FPG), triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were compared in four groups. Logistic multivariate regression analysis was used to investigate the correlation between periodontitis and metabolic syndrome. To observe the changes of metabolic syndrome in patients with periodontitis before and after treatment with traditional Chinese medicine prescription, and to clarify the relationship between related indexes and periodontitis. Results there were significant differences in TG,HDL-C and FPG among the four groups of periodontitis patients (P 0.05), DBP and TC), and there was significant difference in the curative effect of Chinese and western medicine in patients with moderate and severe periodontitis. The index SBP,FPG,TC,TG,LDL-C of metabolic syndrome in patients with obvious effect of traditional Chinese medicine was lower than that before treatment, and the level of HDL-C was higher than that before treatment, and the difference was significant (P 0.05). Conclusion there is a certain correlation between the severity of periodontitis and the index of metabolic syndrome in patients. The effect of traditional Chinese medicine in the treatment of periodontitis is significantly better than that of western medicine.
【作者单位】：山东省滨州医学院附属医院口腔内科;山东省药品审评认证中心审评科;山东省滨州医学院附属医院中心实验室;
【分类号】：R781.42

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