增龄性因素对正畸牙齿移动影响的实验研究

发布时间：2019-06-10 14:22

【摘要】：目的:探索增龄性因素对正畸牙移动过程中牙周组织内HIF-1α及VEGF的影响。方法:建立不同年龄组的正畸牙齿移动动物模型,加力1d、3d、7d、14d及28d,用免疫组化法检测牙周组织中HIF-1α及VEGF的表达情况。结果:青少年组大鼠实验侧压力区HIF-1α表达在加力1d、3d时明显高于成年组大鼠;VEGF表达量在加力1d、3d、7d、14d时明显高于成年组大鼠。结论:增龄性因素可使牙周组织对矫治力的反应速率降低,缺氧调控速率减慢,最终使牙槽骨改建减慢,牙移动速率降低。VEGF参与了正畸牙移动中组织改建过程,但成年组大鼠正畸牙齿移动过程中VEGF表达量增加缓慢,使牙槽骨改建速度降低,造成牙齿移动速度减慢。
[Abstract]:Objective: to explore the effect of aging factors on HIF-1 伪 and VEGF in periodontal tissue during orthodontic tooth movement. Methods: the animal models of orthodontic tooth movement in different age groups were established. The expression of HIF-1 伪 and VEGF in periodontal tissue was detected by immunohistochemistry on the 1st day, 3rd day, 7th day, 14th day and 28th day. Results: the expression of HIF-1 伪 in the experimental lateral pressure area of the juvenile group was significantly higher than that of the adult group at the 1st day and the 3rd day, and the expression of VEGF was significantly higher than that of the adult group at the 1st day, the 3rd day, the 7th day and the 14th day. Conclusion: aging factors can decrease the response rate of periodontal tissue to orthodontic force, slow down the rate of hypoxia regulation, and finally slow down alveolar bone remodeling and tooth movement rate. VEGF is involved in the process of tissue remodeling in orthodontic tooth movement. However, the expression of VEGF increased slowly during orthodontic tooth movement in adult rats, which decreased the rate of alveolar bone remodeling and slowed down the speed of tooth movement.
【作者单位】：首都医科大学附属北京世纪坛医院口腔科;首都医科大学附属北京口腔医院正畸科;
【基金】：国家自然科学基金(编号:61102015) 北京市卫生系统高层次卫生技术人才培养计划(编号:2014-3-078)
【分类号】：R783.5

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