复发性阿弗他溃疡的免疫因素分析
发布时间：2019-06-11 13:32
【摘要】：目的:通过检测与分析RAU患者淋巴细胞亚群及免疫球蛋白,探讨RAU与免疫因素之间的关系,以期应用到今后RAU的临床诊断和治疗中。方法:选择2015年9月至2016年9月于青岛大学附属医院黏膜科就诊的RAU患者,从中筛选出至少有2次RAU复发史,病史在1年以上,且每月发作1次以上的RAU患者44例,尚处于溃疡发作48h以内,且无其他免疫缺陷类疾病,1月内未服抗生素,3月内未服皮质类固醇激素、免疫抑制或调节剂等影响免疫功能的药物者即可抽取其静脉血行免疫球蛋白及淋巴细胞亚群检测,观察免疫各个指标的变化,同时记录自制患者个人信息表,探讨免疫与RAU发病间的关系。结果:44例研究对象中男:女=1.44:1,平均39.3岁;仅细胞免疫异常占总数比例为52%,仅体液免疫异常占总数比例为4.5%,二者皆异常占总数比例为36%,二者皆无异常占总数比例为6.8%;CD3、CD4、CD8、CD4/CD8指标低于正常值者占总数的比率分别为20%、59%、0、73%,指标高于正常值者占总数的比率分别为14%、0、82%、0;Ig A、Ig M、Ig G、Ig E指标高于正常值者占总数的比率分别为7%、0、2%、34%,无低于正常值者;男女患者间Ig A指标存在显著性差异(P0.05),男女RAU患者间其他免疫球蛋白指标无显著性差异(P0.05);男女RAU患者间淋巴细胞亚群无显著性差异(P0.05);40岁以下RAU患者CD3、CD8指标均值高于40岁以上RAU患者,两组间存在显著性差异(P0.05),40岁以下RAU患者CD4、CD4/CD8指标均值低于40岁以上RAU患者,但差异无显著性(P0.05);40岁以下患者与40岁以上患者比较,免疫球蛋白各指标差异无显著性(P0.05)。结论:RAU患者细胞免疫异常比例高于体液免疫异常比例;女性患者的Ig A指标明显高于男性患者;40岁以上RAU患者的CD3、CD8指标明显高于40岁以下RAU患者;RAU患者体内存在细胞免疫功能降低以及体液免疫的异常亢进。
[Abstract]:Objective: to explore the relationship between RAU and immune factors by detecting and analyzing lymphocyte subsets and immunoglobulin in patients with RAU, so as to apply it to the clinical diagnosis and treatment of RAU in the future. Methods: from September 2015 to September 2016, 44 patients with RAU who had a history of recurrence of RAU at least twice, with a history of more than one year and more than once a month, were selected from the Department of Mucology, affiliated Hospital of Qingdao University, and 44 RAU patients with a history of more than one year and more than one attack per month were selected. It was still within 48 hours of ulcer attack, and there were no other immunodeficiency diseases. Antibiotics were not taken in 1 month and corticosteroids were not taken in 3 months. Those who affect immune function, such as immunosuppressive or regulatory agents, can extract their venous blood for immunoglobulin and lymphocyte subsets, observe the changes of immune indexes, and record the personal information table of self-made patients. To explore the relationship between immunity and the incidence of RAU. Results: among the 44 subjects, male: female = 1.44 鈮，
本文编号：2497223
[Abstract]:Objective: to explore the relationship between RAU and immune factors by detecting and analyzing lymphocyte subsets and immunoglobulin in patients with RAU, so as to apply it to the clinical diagnosis and treatment of RAU in the future. Methods: from September 2015 to September 2016, 44 patients with RAU who had a history of recurrence of RAU at least twice, with a history of more than one year and more than once a month, were selected from the Department of Mucology, affiliated Hospital of Qingdao University, and 44 RAU patients with a history of more than one year and more than one attack per month were selected. It was still within 48 hours of ulcer attack, and there were no other immunodeficiency diseases. Antibiotics were not taken in 1 month and corticosteroids were not taken in 3 months. Those who affect immune function, such as immunosuppressive or regulatory agents, can extract their venous blood for immunoglobulin and lymphocyte subsets, observe the changes of immune indexes, and record the personal information table of self-made patients. To explore the relationship between immunity and the incidence of RAU. Results: among the 44 subjects, male: female = 1.44 鈮，
本文编号：2497223
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