服用阿司匹林患者血小板聚集率与上颌牙周炎患牙拔牙创凝血的关系

发布时间：2019-06-13 07:28

【摘要】：目的:探讨服用阿司匹林者在上颌牙周炎患牙拔除后正常凝血所需的血小板聚集率(PAgT)水平和术前合理的停药天数。方法:选取90例接受单颗上颌重度牙周炎患牙拔除的服药者(100 mg/d),分为前牙组(A组)、前磨牙组(B组)和磨牙组(C组),每组30例,包括术前不停药、停药3d和5d者各10例。对其行以花生四烯酸(AA)为诱导剂的光学法血小板聚集率检测(LTA)后实施拔牙,根据拔牙创凝血分级表(Ⅰ级为正常,Ⅱ、Ⅲ级出血量依次增加)评估病例,分析术前不停药、不同停药时间对创面凝血的影响,采用受试者工作特征曲线(ROC curve,SPSS11.6)探讨使用PAgT(AA诱导值)预判术后正常凝血的最佳诊断界值。结果:1Ⅱ级病例在A组中为3例不停药和1例停药3d者,在B组中为5例不停药、2例停药3d和1例停药5d者,在C组中为6例不停药、4例停药3d和1例停药5 d者;3组其余病例为Ⅰ级。2A、B、C组AA诱导值最佳诊断界值分别为10.15%、13.25%和16.5%。结论:服用阿司匹林的患者(100 mg/d)在拔除单颗上颌前牙、前磨牙、磨牙重度牙周炎患牙前经LTA-AA检测,如PAgT≥10.15%、13.25%和16.5%,可预计拔牙创凝血正常,术前可不停药;反之出血量增加,前牙病例可停药3 d,前磨牙、磨牙病例可停药5 d,并完善创面止血措施。
[Abstract]:Objective: to investigate the (PAgT) level of platelet aggregation rate and the reasonable days of drug withdrawal before and after tooth extraction in patients with maxillary periodontitis. Methods: 90 patients with maxillary severe periodontitis were divided into three groups: anterior teeth group (group A), premolar group (group B) and molar group (group C). There were 30 cases in each group, including 10 cases in each group, 10 cases in each group. After (LTA) was detected by optical platelet aggregation rate with arachidonic acid (AA) as inducer, the patients were evaluated according to the grade 鈪，

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