三维打印技术在颅颌面外科中的临床应用

发布时间：2021-02-17 00:42

　　前言颅颌面骨骼的修复因其解剖结构复杂,又毗邻众多重要组织,且由于颅颌面部是个人身份识别的重要标志,有着不可或缺的社交功能,对于个体生活质量有着巨大的影响,颅颌面骨骼的修复对精度有着极高的要求。颅颌面骨骼修复的目标是要同时恢复其美观和功能,这就需要精准的术前设计和术中虚拟设计方案的转化应用。颅颌面骨骼修复的金标准是自体骨移植。然而,由于自体骨移植后骨骼供区的不适、供区取骨加术中雕刻导致手术时间过长,术后感染风险颇高、且无法用于修复过大的骨骼缺损等原因,自体骨移植的应用受到了颇多限制。因此人工骨材料的研究在颅颌面修复领域愈发得到关注。新一代的人工骨材料为可塑性医用树脂和羟基磷灰石（epoxide acrylate maleic andhydroxyapatite,EH）微粒,该材料具有良好的生物相容性、炎性反应小、允许宿主组织长入且吸收量有限;但缺点是材质较脆,术中难以塑形。自20世纪90年代以来,快速成型技术和计算机辅助技术的快速发展,使得它已然成为医疗领域的新宠。过去的十年中,三维打印技术（一种快速成型技术）被广泛应用于定制个性化的手术工具、导向装置和内植物等。快速成型技术（rapid... 

【文章来源】：上海交通大学上海市 211工程院校 985工程院校 教育部直属院校

【文章页数】：100 页

【学位级别】：硕士

【文章目录】：
中文摘要
Abstract Ⅰ
摘要 Ⅰ
Abstract Ⅱ
摘要 Ⅱ
Introduction
PART Ⅰ APPLICATION OF THREE DIMENSIONAL PRINTING TECHNOLOGY BASED ARTIFICIAL BONE IMPLANT IN REPAIR OF MANDIBULAR ASYMMETRICAL DEFORMITY
    1.1.Introduction
    1.2.Aim
    1.3.Methods
        1.3.1.Preoperative planning
            1.3.1.1.Collection of Computed tomographic data
            1.3.1.2.Virtual personalized three dimensional model design
            1.3.1.3.Manufacturing of customized patients specific implants
        1.3.2.Surgical procedures
        1.3.3.Postoperative evaluations
        1.3.4.Statistical analysis
    1.4.Results
    1.5.Discussion
    1.6.Conclusion
    1.7.Limitation
    1.8.Future prospective
PART Ⅱ EVALUATION OF CLINICAL OUTCOMES OF 3D PRINTING GUIDES COMBINE WITH NAVIGATION TECHNIQUE IN REDUCTION OF ZOM COMPLEX FRACTURE
    2.1.Introduction
    2.2.Aim
    2.3.Methods
        2.3.1.Patients selection
        2.3.2.Preoperation
            2.3.2.1. CT scan and three dimensional reconstruction
            2.3.2.2. Virtual Surgical Plan
        2.3.3.Intra-operation
            2.3.3.1. Surgical procedures
        2.3.4.Postoperative management and evaluation
        2.3.5.Statistical analysis
    2.4.Results
        2.4.1.Demographic characteristics
        2.4.2.Unoverlapped volumes percentage and mean deviation between virtualplan and postoperative CT
        2.4.3.Clinical assessment of diplopia severity and clinical assessment of mouthopening and other outcomes
    2.5. Discussion
    2.6. Conclusion
    2.7. Limitation
    2.8. Future prospective
General Conclusion
Bibliography
Acknowledgement
Appendix-Paper
List of Publications



本文编号：3037163