福州市492对母婴麻疹、风疹抗体水平研究

发布时间：2018-02-02 12:28

本文关键词： 麻疹风疹抗体　出处：《中华疾病控制杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的为新生儿麻疹、风疹疫苗的预防接种以及育龄妇女麻疹、风疹疫苗的推广提供科学依据。方法随机选取492对产妇及其新生儿,采集产妇外周血和新生儿脐带血5 ml,使用德国维润/赛润(virion/serion)麻疹、风疹试剂盒,采用酶联免疫吸附测定法(enzyme-linked immunosorbent assay,ELISA)检测麻疹、风疹Ig G抗体。结果产妇麻疹抗体阳性率为94.3%,抗体活性的几何均数(geometric mean titer,GMT)为1:1 264.3;风疹抗体阳性率为82.5%,GMT为1:151.0。新生儿麻疹抗体阳性率为97.6%,GMT为1:1 684.3;风疹抗体阳性率为84.3%,GMT为1:203.8。母婴麻疹(Z=-5.622,P0.001)、风疹(Z=-4.625,P0.001)抗体水平差异有统计学意义,且新生儿抗体水平均高于母亲。母婴麻疹(r=0.924,P0.001)、风疹(r=0.945,P0.001)抗体水平存在正相关关系。结论母传麻疹、风疹抗体存在浓缩效应,婴儿麻疹、风疹抗体水平随母亲抗体水平的升高而升高。加强对育龄妇女麻疹、风疹疫苗的接种,以提高新生儿母传麻疹、风疹抗体水平,有效降低低月龄婴儿的麻疹及风疹发病率。
[Abstract]:Objective to provide a scientific basis for the vaccination of measles and rubella vaccine in newborns and the promotion of measles and rubella vaccine in women of childbearing age. Methods 492 pairs of pregnant women and their newborns were randomly selected. Maternal peripheral blood and umbilical cord blood of newborns were collected. Measles and rubella kit were used to detect measles using Weilun / Serun Virion / serion (Germany) kit. Elisa was used to detect measles by enzyme-linked immunosorbent assayella Elisa. Results the positive rate of measles antibody was 94.30.The geometric mean of antibody activity was 1: 1 264.3; the positive rate of rubella antibody was 1: 151.0; the positive rate of measles antibody in newborn was 1: 1 684.3; the positive rate of rubella antibody was 84.3%; the positive rate of rubella antibody was 84.3%; the positive rate of rubella antibody was 1: 1 684.3; the positive rate of rubella antibody was 1: 1 684.3; the positive rate of rubella antibody was 1: 1 684.3; the positive rate of rubella antibody was 1: 1 684.3; the positive rate of rubella antibody was 1: 1 684.3; For 1: 203.8. the antibody levels of measles in infants and mothers were significantly different from those in measles (P 0.001), and in rubella (P 0.001), and the antibody levels were significantly different between the two groups (P 0.001, P 0.001, P 0.001, P 0.001, P 0.001). The levels of antibodies in newborns were higher than those in mothers. There was a positive correlation between the levels of antibodies against measles and rubella (0.945% P0.001). Conclusion there is a concentration effect of antibodies against measles in mothers and rubella, and there is a positive correlation between the levels of antibodies against measles and measles in infants, and there is a positive correlation between the levels of antibodies against measles and measles in infants. The level of rubella antibody increased with the increase of maternal antibody level. The vaccination of measles and rubella vaccine was strengthened among women of childbearing age in order to increase the antibody level of newborns with measles and rubella and to reduce the incidence of measles and rubella in infants of low age.
【作者单位】：福州市疾病预防控制中心检验科;
【基金】：福州市科技计划项目(2013-S-130-6)
【分类号】：R186;R511
【正文快照】： 随着疫苗时代的到来,麻疹疫苗的覆盖面逐渐加大,人群自然感染的机会大大减少,麻疹疫情的暴发流行鲜有出现。近年来,福州市麻疹发病率虽有下降的趋势,但低月龄婴儿仍有较高的发病率[1]。这可能是由于现在的育龄妇女体内的抗体多数是由主动接种疫苗获取的,而由疫苗获得的抗体在

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