2011-2015年南京市手足口病流行特征及病原学监测分析

发布时间：2018-03-03 14:38

本文选题：手足口病　切入点：流行病学　出处：《现代预防医学》2017年07期 　论文类型：期刊论文

【摘要】：目的对2011-2015年南京市手足口病流行特征及病原学监测进行分析,为进一步工作提供依据。方法收集近五年间南京市报告的所有手足口病病例资料,应用描述性流行病学研究方法进行统计分析。结果五年间,南京市报告该病90 920例,发病率达224.52/10万,有逐年上升趋势(X_(趋势)~2=463.217,P0.001)。重症1 006例,重症病例占全部病例的百分比有逐年下降趋势(P0.001),同时呈现随年龄增加而下降的趋势(P0.001)。发病呈双峰模式;郊区发病率更高,地理上呈现独特的"环形分布"现象;5岁以下儿童高发;男性发病率高于女性。实验室确诊病例4970例,CoxA 16和其他肠道病毒为普通病例的主要病原,而EV71仍然为重症病例的最常见病原。结论手足口病在南京地区的流行呈现出较为明显的季节、地区、人群等分布特征和病原特征,现有措施难以显著降低发病率,需进一步针对性防控措施,加强病原学等监测以及疫苗的研究和推广使用。
[Abstract]:Objective to analyze the epidemic characteristics and etiological surveillance of hand-foot-mouth disease in Nanjing from 2011 to 2015, so as to provide the basis for further work. Methods the data of all HFMD cases reported in Nanjing in recent five years were collected. Results in the past five years, 90,920 cases of the disease were reported in Nanjing, with an incidence of 224.52 / 100 million. The percentage of severe cases in all cases showed a decreasing trend year by year (P 0.001), at the same time it showed a decreasing trend with the increase of age (P 0.001). The incidence of severe cases was in a bimodal pattern, and the incidence rate in the suburbs was higher than that in the suburbs. Geographically, there is a unique "circular distribution" phenomenon in children under 5 years of age. The incidence rate in males is higher than that in females. Laboratory confirmed cases include 4970 cases of CoxA16 and other enterovirus as the main cause of common cases. EV71 is still the most common pathogen of severe cases. Conclusion the prevalence of HFMD in Nanjing shows obvious seasonal, regional, population and other characteristics of distribution and pathogen, the existing measures are difficult to significantly reduce the incidence. Further measures should be taken to prevent and control the disease, to strengthen the surveillance of etiology, and to study and popularize the vaccine.
【作者单位】：南京医科大学公共卫生学院;南京市疾病预防控制中心;江苏省疾病预防控制中心;
【基金】：国家青年自然科学基金(81402732)
【分类号】：R725.1;R181.3

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