2006-2015年陕西省百日咳发病特征及人群抗体水平监测研究

发布时间：2018-03-06 19:04

本文选题：百日咳　切入点：发病特征　出处：《现代预防医学》2017年01期 　论文类型：期刊论文

【摘要】：目的分析陕西省2006-2015年百日咳流行特征及人群抗体水平,为防控策略制定提供参考依据。方法通过描述性方法分析我省近10年百日咳发病特征变化,用酶联免疫吸附实验检测人群血清百日咳抗体水平。结果陕西省2006-2015年百日咳发病整体呈上升趋势,2015年发病率达到1.96/10万,近10年百日咳发病人群主要为0岁组人群,占比67.60%,2014、2015两年关中地区发病率升高明显,百日咳发病时间分布仍主要集中在5~9月份,但由原来的双峰分布变为近年的单峰分布。960份健康人群血清标本Ig G抗体几何平均浓度22.47 IU/ml,阳性701例,阳性率73.02%,3~5岁和6~9岁组抗体几何平均浓度低于其他年龄组,差异具有统计学意义(F=22.73,P0.001)人群抗体水平整体呈高转低再升高的趋势。结论陕西省近年来百日咳发病有升高趋势,同时发病特征有所改变,人群抗体监测发现3~9岁组抗体水平低下,下一步应加强疾病监测敏感性并针对重点地区和易感人群采取必要防控措施。
[Abstract]:Objective to analyze the epidemic characteristics and antibody level of pertussis in Shaanxi province from 2006 to 2015, and to provide reference for the formulation of prevention and control strategy. Results the incidence of pertussis in Shaanxi Province from 2006 to 2015 was on the rise. In 2015, the incidence rate of pertussis reached 19.6 / 100 thousand. In recent 10 years, the population with pertussis was mainly 0 years old. The incidence of pertussis in Guanzhong area increased significantly in the two years from 2014 to 2015, and the time distribution of the onset of pertussis was still concentrated in May and September. However, the geometric mean concentration of IgG antibody in serum samples of 960 healthy people was changed from the original bimodal distribution to the single peak distribution in recent years. The geometric mean concentration of IgG antibody was 22.47 IUP / ml, and 701 cases were positive. The positive rate was 73.02%, and the geometric mean concentration of IgG antibody was lower than that of other age groups (73.02 years old and 69 years old). The difference was statistically significant (P 0.001). Conclusion the incidence of pertussis in Shaanxi Province has an increasing trend in recent years, and the incidence characteristics of pertussis have changed, and the antibody level of the 39-year-old group is lower than that of the control group. The next step is to strengthen the sensitivity of disease surveillance and take necessary prevention and control measures for key areas and susceptible populations.
【作者单位】：陕西省疾病预防控制中心;
【分类号】：R186;R516.6

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