地理环境与健康人血尿素氮参考值的关系

发布时间：2018-03-10 22:04

本文选题：血尿素氮　切入点：地理因素　出处：《吉林大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的:探讨地理环境与健康人血尿素氮BUN参考值的关系,阐明我国健康人BUN参考值的分布规律,为制订不同地区BUN参考值的标准提供科学依据。方法:搜集23个省、4个直辖市、5个自治区403所医疗机构测定的33 521名健康人BUN参考值,选取23项地理数据与健康人BUN参考值进行分析。利用空间自相关分析确定数据空间自相关性,利用相关分析确定与BUN参考值显著相关的地理因素,采用多元线性回归、主成分和岭回归构建预测模型,利用配对样本t检验选取最优预测模型,利用地统计分析构建中国健康人BUN参考值空间分布图。结果:健康人BUN参考值与纬度(X_2)、海拔(X_3)、年平均气温(X_5)、年平均相对湿度(X_6)和年降水量(X_7)5项地理因素指标显著相关,最优预测模型回归方程为Y=5.112+0.000 127 1X_2+0.000 094 61X_3-0.000 140 5X_5-0.000 136 8X_6-0.000 139 1X_7±0.531 0;可得出BUN预测参考值分布图。结论:我国健康人BUN参考值的总体分布趋势为东低西高,BUN参考值与海拔高度呈负相关关系。若已知某一地区的地理数据便可以进行健康人BUN参考值的预测。
[Abstract]:Objective: to explore the relationship between geographical environment and BUN reference value of blood urea nitrogen in healthy people, and to clarify the distribution of reference value of BUN in healthy people in China. Methods: the reference values of 33,521 healthy people were collected from 403 medical institutions in 23 provinces, 4 municipalities directly under the Central Government and 5 autonomous regions. The data spatial autocorrelation was determined by spatial autocorrelation analysis, the geographic factors significantly related to BUN reference value were determined by correlation analysis, and multivariate linear regression was used. The prediction model was constructed by principal component and ridge regression, and the optimal prediction model was selected by paired sample t-test. The spatial distribution of BUN reference values of healthy people in China was constructed by using geostatistical analysis. Results: the reference values of BUN in healthy people were significantly correlated with five geographic factors, I. e., the reference values of BUN in healthy people and the five geographic factors, I. e., Latitude X _ 2, altitude X _ 3, annual mean air temperature X _ 5, annual average relative humidity X _ 6) and annual precipitation X _ (7). The regression equation of the optimal prediction model is YJ 5.112 0.000 1271Xpopulation 20 0.000 094 61Xtig 3-0.000 1405XL 5-0.000 1368X6-0.0001391X7 卤0.531 00.The BUN prediction reference value distribution map can be obtained. Conclusion: the general distribution trend of the BUN reference value of healthy people in our country is the reference value of BUN in the east and west and the altitude high. If the geographical data of a certain area are known, the BUN reference value of healthy people can be predicted.
【作者单位】：陕西师范大学旅游与环境学院健康地理研究所;地理学国家级实验教学示范中心(陕西师范大学);西安交通大学医学院第二附属医院心内科;
【基金】：国家自然科学基金资助课题(40971060) 中央高校基本科研业务费专项资金资助课题(2016CSY012)
【分类号】：R188

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