深圳市儿童血清微量元素硒水平与手足口病感染的关系研究

发布时间：2018-03-22 23:24

  本文选题：手足口病　切入点：微量元素　出处：《现代预防医学》2017年18期 　论文类型：期刊论文

【摘要】：目的探讨深圳市儿童血清中微量元素硒(Se)水平与手足口病感染的相关性。方法于2013-2015年间在深圳市儿童医院采集手足口病病例422例和健康儿童208例的咽拭子/肛拭子样本及血样。采用实时荧光定量PCR检测咽拭子/肛拭子病原体类型。用电感耦合等离子质谱法(ICP-MS)分析血清中Se含量。结果病例组血清Se水平低于对照组(P0.001),而在重症与轻症间差异无统计学意义(P=0.371);重症、轻症和健康组血清Se水平在性别间差异均无统计学意义(P0.05);在重症和轻症组中,≤3岁患儿血清Se水平均低于3岁组患儿(P0.05),而健康儿童年龄组间差异无统计学意义(P=0.207);血清Se水平在EV71、CA16与其他病毒感染组间差异无统计学意义(P=0.985);Spearman秩相关分析结果显示病情与血清Se水平负相关(P0.001),同时Logistic回归结果显示高Se水平是手足口病患儿的保护因素(OR值1,P0.05)。结论儿童手足口病感染与微量元素Se有关,加强儿童血清Se水平监测与评估,做到及时补充,对增强免疫力和改善病情具有一定的意义。
[Abstract]:Objective to investigate the correlation between serum selenium (se) and infection of HFMD in children in Shenzhen. Methods 422 HFMD cases and 208 healthy children were collected from Shenzhen Children's Hospital from 2013 to 2015. Methods pharynx swabs / anal swabs were collected from 208 healthy children. The pathogen types of pharynx swab and anal swab were detected by real-time fluorescence quantitative PCR. The serum se content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). The results showed that the serum se level in the case group was lower than that in the control group (P 0.001), while in the control group, the level of se in the patient group was significantly lower than that in the control group (P 0.001). There was no significant difference between severe and mild diseases. There was no significant difference in serum se levels between the two groups (P 0.05), while in the severe and mild groups, there was no significant difference in serum se levels between the two groups. The serum se level of children 鈮，

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