肺癌化疗老年患者医院感染调查及免疫功能分析

发布时间：2018-03-24 09:25

本文选题：肺癌　切入点：化疗　出处：《中华医院感染学杂志》2014年19期

【摘要】：目的研究肺癌化疗老年患者免疫功能和医院感染情况,为临床治疗提供参考依据。方法选取2009年3月-2013年3月在医院进行化疗的老年肺癌患者150例作为研究对象,根据是否出现医院感染分为感染组26例与未感染组124例;对感染组患者的临床资料、病原菌进行分析,并比较两组患者的免疫功能,采用SPSS17.0进行统计分析。结果 150例化疗的老年肺癌患者当中有26例患者发生医院感染,感染率为17.33%,17例患者医院感染发生在化疗后1周以内,感染率65.38%,9例患者发生在化疗后2~4周,感染率34.62%;主要感染部位为上呼吸道占38.46%、下呼吸道占26.92%和胃肠道占15.38%;26例医院感染患者共检出病原菌32株,革兰阴性菌19株,占59.38%,革兰阳性菌9株,占28.12%;真菌4株,占12.50%。结论化疗后患者的免疫功能可能出现不同程度的受损,增加了医院感染的发生风险,可在患者化疗前后给予免疫功能调节治疗和健康干预措施。
[Abstract]:Objective to study the immune function and nosocomial infection in elderly patients undergoing chemotherapy for lung cancer, and to provide reference for clinical treatment. Methods 150 elderly lung cancer patients undergoing chemotherapy in hospital from March 2009 to March 2013 were selected as the study objects. According to whether nosocomial infection occurs, there are 26 cases in the infection group and 124 cases in the uninfected group. The clinical data and pathogenic bacteria of the infected group are analyzed, and the immune function of the two groups is compared. Results Nosocomial infection occurred in 26 out of 150 elderly patients with lung cancer treated with chemotherapy. The nosocomial infection rate was 17.33. The nosocomial infection occurred within 1 week after chemotherapy, and the infection rate was 65.38% in 9 patients at 2 ~ 4 weeks after chemotherapy. The main sites of infection were upper respiratory tract (38.46%), lower respiratory tract (26.92%), gastrointestinal tract (15.38%), pathogenic bacteria (32 strains), gram-negative bacteria (19 strains), gram-positive bacteria (9 strains) and fungi (28.12%). Conclusion the immune function of patients after chemotherapy may be damaged in varying degrees, which increases the risk of nosocomial infection, and can be treated with immune function regulation and health intervention before and after chemotherapy.
【作者单位】：聊城市人民医院肿瘤科综合Ⅰ病房;
【基金】：山东省自然科学青年基金资助项目(Q2006C02)
【分类号】：R181.32

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