上海市社区高血压人群肾脏损害的流行病学研究

发布时间：2018-04-03 13:34

本文选题：高血压　切入点：肾脏损害　出处：《复旦大学》2009年硕士论文

【摘要】： [目的]为了解我国城市中高血压人群中肾脏早期损害的患病率并分析其影响因素,在此基础上结合文献回顾,提出防治肾脏早期损害的对策建议。 [方法]采用分层整群抽样方法,对上海市大华社区中23个居委和3个村按照居住情况和经济条件状况分别抽取3个条件较好的居委和1个相对较差的村,结合户籍资料及居委会的人口登记资料,由大场社区卫生服务中心的社区医生,经统一培训后对所有常住于本区域的高血压居民,进行项目为封闭式的现场问卷调查。调查表整理后进行数据录入到SPSS13.0数据库,采用频数分析、T检验、单因素分析、logistic分析等进行统计分析。 [结果]在大场社区654例资料完整的高血压患者居民中,男女比例为1:1.8,平均年龄为61岁。微量白蛋白尿的患病率为24.8%,其中男性患病率29.1%,女性患病率22.4%。肾功能下降的患病率为14.8%,其中男性患病率13.0%,女性患病率18.5%。单因素分析结果:微量白蛋白尿与血低密度脂蛋白、吸烟、BMI、血尿酸、血压控制效果有关,与血胆固醇、血甘油三脂、血高密度脂蛋白、血糖、腰围、高血压的病程无关。肾功能下降与年龄、血低密度脂蛋白、BMI有关,与血胆固醇、血甘油三脂、血高密度脂蛋白、血糖、血尿酸、腰围、吸烟、高血压的病程、血压控制效果无关。多因素Logistic回归分析提示:LDL-c、BMI和病程是UMA的危险因素,LDL-c和BMI是GFR的危险因素,服药是GFR的保护因素。 [结论]在我国大城市高血压人群中肾脏早期损害的患病率24.8%,肾功能下降的患病率为14.8%,与国外研究相似。建议进行肾脏早期损害的检测、规范治疗。
[Abstract]:[objective] in order to understand the prevalence of early renal damage in urban hypertensive population and analyze its influencing factors, based on the review of literature, the countermeasures and suggestions for prevention and treatment of early renal damage were put forward.[methods] A stratified cluster sampling method was used to select 3 better neighborhood committees and 1 relatively poor village according to the living conditions and economic conditions in 23 and 3 villages of Dahua community in Shanghai, respectively.Based on the household registration data and the population registration data of the residents' committee, the community doctors of Dachang Community Health Service Center, after unified training, conducted a closed field questionnaire survey for all the residents of hypertension living in this area.The data were recorded into the SPSS13.0 database after the questionnaire was processed, and the frequency analysis T test, single factor analysis and logistic analysis were used for statistical analysis.[results] among 654 patients with hypertension in Dachang community, the ratio of male to female was 1: 1.8 with an average age of 61 years.The prevalence of microalbuminuria was 24.8%, including 29.1% for males and 22.4% for females.The prevalence rate of renal function decline was 14.80.The prevalence rate of male was 13.0 and that of female was 18.5.Univariate analysis showed that microalbuminuria was related to low density lipoprotein (LDL), smoking BMI, serum uric acid and blood pressure control effect, but not related to blood cholesterol, triglyceride, high density lipoprotein, blood glucose, waist circumference and the course of hypertension.The decline of renal function was related to age, low density lipoprotein BMI, but not to cholesterol, triglyceride, high density lipoprotein, blood glucose, uric acid, waist circumference, smoking, the course of hypertension, and the effect of blood pressure control.Multivariate Logistic regression analysis showed that Logistic and course of disease were risk factors of UMA. LDL-c and BMI were risk factors of GFR, and medication was the protective factor of GFR.[conclusion] the prevalence of early renal damage was 24.8in the hypertensive population in big cities of China, and the prevalence rate of renal function decline was 14.8. it is similar to foreign studies.It is suggested that early renal damage should be detected and standardized treatment should be made.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2009
【分类号】：R544.1;R181.3

【参考文献】