2010～2015年河北省EV-A71病原流行及分子特征分析

发布时间：2018-04-04 22:04

本文选题：手足口病(HFMD)　切入点：病原　出处：《病毒学报》2017年06期

【摘要】：为了掌握河北省2010~2015年手足口病主要病原EV-A71的流行及分子特征,并探讨EV-A71构成情况和重症及死亡病例的相关性,为手足口病的防控提供科学依据。采用Spearman秩相关分析方法对各月度EV-A71构成比分别与各月份全省报告病例数、重症病例数、死亡病例数等指标的关系进行分析,利用DNAstar软件包和MEGA软件分析EV-A71病毒的基因进化特征。2010年1月至2015年12月间,河北省各月份EV-A71构成比与重症病例数、死亡病例数、重症率及病死率之间相关系数分别为0.31、0.38、0.57和0.45(P值均小于0.01)。河北省EV-A71分离株均属C4a亚型。EV-A71是引起河北省大多数手足口病重症和死亡病例的主要病原体。各月份EV-A71构成比与手足口病重症病例数、死亡病例数、重症率及病死率之间存在一定正相关的关系。
[Abstract]:In order to understand the prevalence and molecular characteristics of EV-A71, the main pathogen of hand, foot and mouth disease in Hebei Province from 2010 to 2015, and to explore the relationship between EV-A71 composition and severe and death cases, the scientific basis was provided for the prevention and control of hand, foot and mouth disease.Spearman rank correlation analysis was used to analyze the relationship between the monthly EV-A71 composition ratio and the number of reported cases, the number of severe cases and the number of death cases in the province in each month.DNAstar software package and MEGA software were used to analyze the gene evolution characteristics of EV-A71 virus. From January 2010 to December 2015, the ratio of EV-A71 composition to severe cases and the number of death cases in Hebei Province were analyzed.The correlation coefficient between severe disease rate and mortality were 0.31 ~ 0.38 ~ (0.57) and 0.45 ~ (-1) P < 0.01 ~ (-1) respectively.The isolates of EV-A71 in Hebei Province are all C4a subtypes. EV-A71 is the main pathogen causing the severe and death cases of HFMD in Hebei Province.There was a positive correlation between EV-A71 composition ratio and the number of severe hand, foot and mouth disease cases, the number of death cases, the severe disease rate and the fatality rate in each month.
【作者单位】：河北省疾病预防控制中心病毒病防治所;华北理工大学公共卫生学院;
【基金】：河北省科技计划项目(172777111D);题目:新一代测序技术在手足口病肠道病毒分型鉴定中的应用研究河北省重大医学科研资助项目(zd2013068);题目:手足口病流行的影响因素与干预措施研究~~
【分类号】：R181.3;R512.5

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