上海市静安区水痘聚集性疫情中1剂次水痘减毒活疫苗保护效果观察

发布时间：2018-04-10 00:01

本文选题：水痘减毒活疫苗　切入点：保护效果　出处：《中国疫苗和免疫》2017年05期

【摘要】：目的分析2013-2016年上海市静安区水痘聚集性疫情中儿童接种1剂次水痘减毒活疫苗(Varicella attenuated live vaccine,VarV)的保护效果(Vaccine effectiveness,VE)。方法收集2013-2016年静安区所有发生水痘聚集性疫情学校和托幼机构的儿童VarV接种和水痘发病信息,分析VarV的VE。结果在5 309名观察对象中,接种和未接种VarV者中的水痘病例分别占5.5%(252/4 586)、9.4%(68/723)。接种1剂次VarV的总VE为44.0%(95%CI:25.9%-57.7%);VE随接种年限延长而降低,接种满3年后VE下降明显,接种满8年后VE已无统计学意义。结论 1剂次VarV的VE较差,建议儿童在1岁和4岁进行2剂次VarV常规免疫。
[Abstract]:Objective to analyze the protective effect of vaccine effectivities on children vaccinated with 1 dose of live attenuated varicella attenuated live varicella varicella live varicella virus in chickenpox agglomeration epidemic situation in Jing'an District of Shanghai from 2013 to 2016.Methods the information of VarV vaccination and chickenpox incidence in all chickenpox agglomeration schools and nurseries in Jing'an District from 2013 to 2016 were collected and analyzed.Results among 5 309 observed subjects, the proportion of varicella cases in vaccinated and uninoculated VarV patients was 5.5 / 252P / 4586 / 9.40.68 / 723g respectively.The total VE of the first dose of VarV was 44.0% and 95% CI: 25.9-57.7%. The VE decreased with the extension of inoculation time. After 3 years of inoculation, the VE decreased obviously, but after 8 years of inoculation, there was no significant difference in VE.Conclusion VE of the first dose of VarV is poor. Children aged 1 and 4 years should be given 2 doses of routine VarV immunization.
【作者单位】：上海市静安区疾病预防控制中心;
【基金】：上海市卫生和计划生育委员会科研课题(20154Y0093)
【分类号】：R186

【相似文献】