海口市2003-2012年卡介苗疑似预防接种异常反应监测分析

发布时间：2018-04-24 21:11

本文选题：卡介苗 + 疑似预防接种异常反应　；参考：《现代预防医学》2014年10期

【摘要】：目的分析海口市卡介苗(Bacille Calmette-Guerin Vaccine,BCG)疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,评价BCG的安全性和监测情况。方法通过以往疑似异常反应报告登记信息和全国AEFI信息管理系统,收集2003-2012年报告的接种BCG剂次数及接种后AEFI个案数据,采用描述性方法对相关指标进行流行病学分析。结果 2003-2012年共报告接种BCG后AEFI 83例,报告发生率为313.15/100万剂,其中不良反应78例,报告发生率为294.29/100万剂。不良反应中,一般反应4例,报告发生率为15.09/100万剂;异常反应74例,报告发生率为279.19/100万剂。报告最多的异常反应为BCG淋巴结炎,共72例,报告发生率为271.6/100万剂。1例BCG接种事故主要是接种剂量过大。结论 BCG安全性尚可,海口市BCG淋巴结炎高于我国监测报告水平。应继续加强培训和督导,提高接种人员接种技术,规范预防接种操作;增强BCG AEFI监测敏感性和AEFI的调查诊断,减少AEFI的发生和相关纠纷的产生。
[Abstract]:Objective to analyze the characteristics of Events Events Following immunizationin Haikou City, and to evaluate the safety and monitoring of BCG. Methods through the registration information of suspected abnormal reaction reports and the national AEFI information management system, the reported times of BCG inoculation and the AEFI case data after inoculation from 2003 to 2012 were collected, and the epidemiological analysis of related indexes was carried out by descriptive method. Results from 2003 to 2012, 83 cases of AEFI after inoculation with BCG were reported, the reported incidence rate was 313.15 / 1 million doses, including 78 cases of adverse reactions and 294.29 / 1 million doses of AEFI. Adverse reactions were reported in 4 cases with a reported incidence of 15.09 / 1 million doses and abnormal reactions in 74 cases with a reported incidence of 279.19 / 1 million doses. The most reported abnormal reaction was BCG lymphadenitis (72 cases). The reported incidence rate was 271.6% 1 million doses of 1. 1 BCG inoculation accident was mainly due to excessive inoculation dose. Conclusion BCG is safe, BCG lymphadenitis in Haikou City is higher than that in China. We should continue to strengthen training and supervision, improve inoculation technology, standardize inoculation operation, enhance the sensitivity of BCG AEFI monitoring and the investigation and diagnosis of AEFI, and reduce the occurrence of AEFI and related disputes.
【作者单位】：海南省海口市疾病预防控制中心;
【分类号】：R186

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