成年人群非酒精性饮料与抑郁症状的关联性研究

发布时间：2018-04-24 23:11

  本文选题：抑郁症状 + 绿茶　； 参考：《天津医科大学》2017年硕士论文

【摘要】：目的:抑郁症已成为严重的世界性公共卫生问题,研究表明饮食与其关系密切。本研究旨在通过评价天津人群非酒精性饮料(绿茶、乌龙茶、红茶、咖啡、碳酸饮料、果蔬汁)的摄入情况和抑郁症状水平,探究不同非酒精性饮料与抑郁症状的关联。方法:本研究利用2013-2015年“天津人群慢性低度系统性炎症与健康”队列的基线人群进行一项大型的横断面研究。同意参加研究并满足纳入、排除标准的研究对象共有19,224人。本研究所涉及变量如下:问卷调查变量(社会人口学情况、生活习惯情况、运动与饮食情况、家族疾病史、个人疾病史等)、体格检查变量(身高、体重、血压等)和血液生化检查变量(空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等)。抑郁症状利用经验证的中文版抑郁自评量表进行评价,并以40为截断值来指示有无抑郁症状;非酒精性饮料的摄入利用结构化食物频率问卷进行评价。最终分析采用多元Logistic回归分析来评价男性、女性人群中非酒精性饮料与抑郁症状之间的关联。结果:本研究总人群抑郁症状存在率为35.2%,而男、女人群的存在率分别为33.3%和37.4%。经过不同混杂因素的调整,结果显示不同的非酒精性饮料与抑郁症状之间存在着不同关联。在调整众多混杂因素的最终模型中(调整了年龄、体质指数、吸烟状况、饮酒状况、身体活动、婚姻状况、教育程度、职业类型、家庭总收入、亲友来往情况、独居情况、总能量摄入、代谢综合征、EPA+DHA摄入和其他各种非酒精性饮料),有如下发现:1.男性、女性人群中均未观察到摄入不同类型的茶(绿茶、红茶、乌龙茶)与抑郁症状之间存在有意义的关联。2.仅在男性人群中观察到每周摄入≥4杯咖啡与较高的抑郁症状存在率有关,即多种混杂因素调整后发现,与每周?1杯咖啡相比,每周2-3杯和每周≥4杯咖啡的抑郁症状比值比(OR)(95%置信区间,95%CI)分别为1.00(0.81,1.23)和1.25(1.02,1.53)(趋势性P0.01)。但女性人群并未发现有意义的关联。3.男性、女性中均观察到碳酸饮料或果蔬汁与抑郁症状之间有意义的关联,即多因素调整后发现,与每周?1杯相比,每周摄入≥4杯碳酸饮料的抑郁症状存在率在男、女人群中分别增加31%、83%,而每周摄入≥4杯果蔬汁的抑郁症状存在率在男、女人群中各增加65%、24%。结论:本文首次全面地探讨了各种非酒精性饮料与抑郁症状之间的关联,并发现不同非酒精性饮料与抑郁症状存在不同关联。今后需要更多研究探讨并明确各类非酒精性饮料与抑郁症状的关联,明确因果关系,并阐明其中的作用机制。
[Abstract]:Objective: depression has become a serious public health problem worldwide. The purpose of this study was to explore the relationship between non-alcoholic beverages and depression symptoms by evaluating the intake and depression symptoms of non-alcoholic beverages (green tea, oolong tea, black tea, coffee, carbonated drinks, fruit and vegetable juice) in Tianjin. Methods: a large cross-sectional study was conducted in the baseline population of Tianjin population cohort of chronic low systemic inflammation and Health from 2013 to 2015. A total of 19224 subjects agreed to participate in the study and meet the inclusion, exclusion criteria. The variables involved in this study are as follows: questionnaire variables (social demography, living habits, exercise and diet, family disease history, personal disease history, etc.), physical examination variables (height, weight, etc.) Blood biochemical variables (fasting blood glucose, triglyceride, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, etc. Depressive symptoms were evaluated with the Chinese version of the self-rating depression scale and 40 as the cut-off value to indicate whether there were depression symptoms. The intake of non-alcoholic drinks was evaluated by structured food frequency questionnaire. Multivariate Logistic regression analysis was used to evaluate the association between non-alcoholic beverages and depression symptoms in men and women. Results: the prevalence of depressive symptoms was 35.2g in the total population, and 33.3% in males and 37.4% in females. After adjusting for different confounding factors, the results showed that there were different correlations between different non-alcoholic beverages and depression symptoms. In the final model (adjusted for age, body mass index, smoking status, alcohol consumption, physical activity, marital status, education, type of occupation, total family income, family and friends, and living alone), Total energy intake, metabolic syndrome DHA intake and other non-alcoholic beverages, have been found as follows: 1. 1. No significant association was observed between the intake of different types of tea (green tea, black tea, and oolong tea) and depression symptoms in both men and women. It was observed that intake of more than 4 cups of coffee a week was associated with a higher prevalence of depression symptoms only in men, that is, after adjusting for multiple confounding factors, it was found that, compared with one cup of coffee per week, The depression symptom ratios of 2-3 cups per week and 鈮，

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