2011-2015年陕西省克雅氏病监测病例特征分析

发布时间：2018-04-26 21:25

本文选题：克雅氏病 + 监测　；参考：《中国人兽共患病学报》2017年11期

【摘要】：目的了解陕西省克雅氏病(Creutzfeldt-Jakob disease,CJD)的发病情况、临床表现及流行病学特征,为科学防控CJD提供依据。方法采集了2011-2015年陕西省7家医院报告的49例可疑CJD病例的临床及流行病学信息,收集了患者的血液及脑脊液样本。对脑脊液样本,通过免疫印迹法检测14-3-3蛋白。对血液样本,提取核酸,通过聚合酶链反应,扩增朊蛋白基因;利用测序技术,测定其突变情况,同时对129位和219位氨基酸进行多态性分析。结果确定散发型CJD临床诊断病例16例,散发型CJD疑似诊断病例4例,遗传型CJD 1例。病例的地理分布和职业无明显聚集性;散发型CJD临床诊断病例发病年龄中位数为62岁,男女比例1.29∶1;快速进行性痴呆为最常见的首发症状,占全部诊断病例的47.62%。结论陕西监测到的CJD病例主要为散发型CJD,收集到的病例的年龄、性别比例、职业情况及住址分布等均符合散发型CJD的分布特点。
[Abstract]:Objective to investigate the incidence, clinical manifestation and epidemiological characteristics of Creutzfeldt-Jakob disease (CJDD) in Shaanxi Province, so as to provide scientific basis for the prevention and control of CJD. Methods the clinical and epidemiological information of 49 suspected CJD cases reported in 7 hospitals in Shaanxi Province from 2011 to 2015 were collected and the blood and cerebrospinal fluid samples were collected. The 14-3-3 protein was detected by Western blotting in cerebrospinal fluid (CSF) samples. Nucleic acid was extracted from blood samples and prion gene was amplified by polymerase chain reaction (PCR). The mutation of prion protein gene was determined by sequencing and the polymorphism of 129 and 219 amino acids was analyzed. Results 16 cases of sporadic CJD were clinically diagnosed, 4 cases of sporadic CJD were suspected, and 1 case of hereditary CJD was found. The median age of clinical diagnosis of sporadic CJD was 62 years old, the ratio of male to female was 1.29: 1, and rapid progressive dementia was the most common initial symptom, accounting for 47.62% of all cases. Conclusion the main CJD cases monitored in Shaanxi are sporadic CJD. The age, sex ratio, occupation status and address distribution of the collected cases are consistent with the distribution characteristics of sporadic CJD.
【作者单位】：陕西省疾病预防控制中心病毒病预防控制所;
【基金】：“十二·五”国家科技重大专项(No.2013ZX10004202-001-002)~~
【分类号】：R181.3;R742.9

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