中国肺结核治疗失败影响因素的Meta分析

发布时间：2018-04-29 15:14

  本文选题：结核 + 肺　； 参考：《中华疾病控制杂志》2014年02期

【摘要】：目的探讨肺结核治疗失败的影响因素,为今后防治工作提供依据。方法对PubMed、CNKI、VIP、CBM及万方数据库进行检索关于肺结核治疗失败影响因素的研究(2002-2012年),通过Meta分析,报告危险因素的合并OR(95%CI)值。结果共纳入符合标准的文献15篇,单因素分析,合并OR(95%CI)值分别为:合并症2.71(1.99~3.70)、肺病空洞2.16(1.75~2.66)、病变肺野数4.88(2.76~8.62)、低蛋白血症3.57(2.61~4.90)、不规律治疗28.09(4.90~161.06)、治疗延误3个月5.42(1.53~19.15)、吸烟3.47(2.20~5.46)、不良反应2.08(1.46~2.98)、耐药3.30(1.24~8.76);多因素分析,OR(95%CI)值分别为:合并症2.51(1.85~3.41)、肺部空洞1.77(1.39~2.26)、病变肺野数1.38(1.26~1.51)、不规律治疗19.83(2.83~138.76)、治疗延误3个月2.35(1.42~3.91)、不良反应2.14(1.49~3.06)、耐药2.45(1.37~4.38),指标差异均有统计学意义。结论合并症、肺部空洞、病变肺野数、低蛋白血症、不规律治疗、治疗延误、吸烟、不良反应、耐药均是肺结核治疗失败的影响因素。
[Abstract]:Objective to explore the factors influencing the failure of pulmonary tuberculosis treatment and to provide basis for future prevention and treatment. Methods the study on the influencing factors of pulmonary tuberculosis failure was carried out by searching the CBM of CNKI Meta and Wanfang database. By Meta analysis, the combined OR95 value of risk factors was reported. Results A total of 15 articles were included to meet the criteria, and a single factor analysis was carried out. 鍚堝苟OR(95%CI)鍊煎垎鍒�涓�:鍚堝苟鐥，

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