无锡市新型布尼亚病毒感染情况调查分析

发布时间：2018-05-05 19:38

本文选题：正布尼亚病毒属 + 病毒　；参考：《中华疾病控制杂志》2014年03期

【摘要】：目的对无锡市人群、动物及节肢类虫媒生物新布尼亚病毒感染情况,分析感染谱、流行病学特点及影响因素,为控制疫情提供依据。方法采用统一的诊断标准调查病例,双抗原夹心酶联免疫吸附测定法(enzymelinked immunosorbent assay,ELISA)法检测血清特异性总抗体,采用逆转录-聚合酶链反应(reverse transcription-polymerase chain reaction,RT-PCR)法进行病原学诊断。结果 2010-2011年,共调查发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)疑似病例66例,疑似病例确诊阳性率为7.58%,确诊病例病死率为60.00%(3/5)。一般人群总抗体阳性率为0.23%(2/866);家畜类动物337只,抗体阳性率为2.08%,阳性率较高的动物为鹅(33.33%)、羊(6.76%)和鸡(0.67%);野生类动物115只,抗体阳性率为1.74%,阳性率较高的动物为鼠(2.13%)。节肢类虫媒生物中未发现核酸检测阳性者。结论初步确认新布尼亚病毒感染谱包括隐性感染和显性感染(包括轻症病例、重症病例和死亡病例);该病可能为人畜共患病,可能宿主动物为鼠、羊和鸡;年龄偏大和生活在丘陵地区可能是SFTS发病的危险因素。
[Abstract]:Objective to analyze the infection spectrum, epidemiological characteristics and influencing factors of new Bunia virus in Wuxi population, animals and arthropods in order to provide the basis for controlling the epidemic situation. Methods Serum specific total antibodies were detected by double antigen sandwich immunosorbent Elisa and reverse transcription-polymerase chain reactionation reverse polymerase chain reaction (RT-PCR) were used to detect the etiology. Results from 2010 to 2011, 66 suspected cases of fever with severe fever with thrombocytopenia syndromes were investigated. The positive rate of confirmed cases was 7.58, and the fatality rate of confirmed cases was 60.005 / 5%. The total antibody positive rate of the general population was 0.23 / 866, the positive rate of antibody was 2.08 in 337 domestic animals, and the higher positive rate was geese 33.3333 and 0.677.The wild animals had 115 wild animals, the positive rate of antibody was 1.74, and the higher positive rate was 2.13B. No nucleic acid positive was found in arthropods. Conclusion New Bunia virus infection spectrum includes recessive infection and dominant infection (including mild cases, severe cases and death cases), which may be zoonotic, possibly host animals are mice, sheep and chicken. Age and living in hilly areas may be risk factors for SFTS.
【作者单位】：南京医科大学公共卫生学院流行病与卫生统计学系;无锡市疾病预防控制中心疾病控制部;宜兴市疾病预防控制中心防疫科;
【基金】：无锡市科技发展计划(CSE01N1120) 无锡市卫生局重大项目(G201201) 宜兴市民生科技示范工程建设推进计划(2012-06)
【分类号】：R181.3

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