北京市顺义区中小学生甲型H1N1流感血清流行病学调查

发布时间：2018-05-05 18:49

本文选题：流感病毒A型 + HN亚型　；参考：《中国学校卫生》2014年05期

【摘要】：目的了解顺义区中小学生甲型H1N1流感抗体水平及变化趋势,为预测该病在学校的流行趋势提供依据。方法于2010年1月—2011年4月,采用多阶段分层随机抽样方法,4次共抽取顺义区891名中小学生进行问卷调查,并采集血清检测甲型H1N1流感抗体水平。结果中小学生甲型H1N1抗体阳性率为53.0%,平均抗体滴度为1∶27.8,抗体阳性者滴度水平主要集中在1∶40~1∶320,占总体阳性数的96.8%。2010年1月、3—4月、7—8月和2011年3—4月4个时间点人群抗体阳性率分别为40.9%,73.8%,52.9%和42.7%,差异有统计学意义(P值均0.01),自2010年3—4月起抗体阳性率有随时间而下降的趋势(P0.05)。抗体阳性率的性别间差异无统计学意义(P0.05),不同年龄组、城乡、学段间学生抗体阳性率差异均有统计学意义(P0.01)。结论顺义区多数学生具有甲型H1N1流感病毒保护性抗体,学生抗体阳性率有随时间下降的趋势。需加强对学生宣教,实施流感疫苗接种措施。
[Abstract]:Objective to investigate the level and trend of influenza A (H1N1) antibody in primary and middle school students in Shunyi district, and to provide basis for predicting the epidemic trend of the disease in schools. Methods from January 2010 to April 2011, a total of 891 primary and middle school students in Shunyi district were selected four times by multi-stage stratified random sampling, and the serum samples were collected to detect the level of influenza A (H1N1) antibody. Results the positive rate of H1N1 antibody in primary and middle school students was 53.0 and the average titer of antibody was 1: 27.8.The titer of antibody positive was mainly 1: 401320, accounting for 96.80.The number of positive in January, 2010, March-April, July to August, and 2011, 3-4. The positive rates of antibody were 40.9% and 42.7%, respectively. The difference was statistically significant (P < 0.01). Since March-April 2010, the positive rate of antibody decreased with time (P 0.05%). There was no significant difference in antibody positive rate between sexes. There was significant difference in antibody positive rate among students in different age groups, urban and rural areas. Conclusion most students in Shunyi District have protective antibodies against influenza A H1N1 virus, and the positive rate of antibodies among students has a tendency to decrease with time. It is necessary to strengthen the education of students and implement the measures of influenza vaccination.
【作者单位】：北京市顺义区疾病预防控制中心;
【分类号】：R181.36;R511.7

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