广东省肇庆市2012年全人群麻疹、风疹、流行性腮腺炎抗体水平调查

发布时间：2018-05-29 06:31

本文选题：麻疹 + 风疹　；参考：《中国疫苗和免疫》2015年05期

【摘要】：目的了解肇庆市全人群麻疹、风疹、流行性腮腺炎抗体水平,为控制相应疾病、改善免疫策略提供科学依据。方法按分层随机原则抽取肇庆市三个县区2012年全人群血清标本共319份,用酶联免疫吸附试验定量检测麻疹、风疹、流行性腮腺炎Ig G抗体水平。结果肇庆市2012年全人群麻疹抗体阳性率为88.40%、抗体几何平均浓度(Geometric Mean Concentration,GMC)为1167.95m IU/ml;风疹抗体阳性率为78.06%、GMC为146.10IU/ml;流行性腮腺炎抗体阳性率为74.92%,GMC为447.96U/ml。人群麻疹、风疹抗体阳性率在不同县区、年龄段、性别、城乡之间没有统计学差异;流行性腮腺炎抗体阳性率在城乡之间没有统计学差异,在不同县区、不同年龄段、性别之间有统计学差异(X~2=9.760,P0.05;X~2=36.509,P0.05;X~2=5.575,P0.05);低龄儿童麻疹、风疹、流行性腮腺炎抗体阳性率和GMC偏低,20~29岁年龄段人群麻疹、风疹抗体阳性率和GMC不高。结论肇庆市全人群对麻疹、风疹、流行性腮腺炎疾病已建立一定的免疫屏障,但应加强对低龄儿童的预防接种工作,及时为8~11月龄儿童接种麻疹风疹联合减毒活疫苗(MR)、1.5岁以上儿童接种麻腮风联合减毒活疫苗(MMR);建议为20~29岁育龄期妇女接种MR或MMR,进一步提高全人群防病水平。
[Abstract]:Objective to understand the antibody levels of measles, rubella and mumps in Zhaoqing city, and to provide scientific basis for controlling the disease and improving the immune strategy. Methods 319 serum samples were collected from the whole population of Zhaoqing city in 2012 according to the principle of stratification and randomization, and the IgG antibody levels of measles, rubella and mumps were detected quantitatively by enzyme linked immunosorbent assay (Elisa). Results the positive rate of measles antibody was 88.40 in the whole population of Zhaoqing city in 2012, the geometric average concentration of antibody was 1167.95 渭 mol / ml, the positive rate of rubella antibody was 146.10 U / ml, and the positive rate of mumps antibody was 447.96 U / ml. The positive rates of measles and rubella antibodies in different counties, age groups, sexes, and urban and rural areas were not statistically different. There was no statistical difference in the positive rates of mumps antibodies between urban and rural areas, but in different counties and different age groups, There was a statistical difference between the two sexes, and the positive rates of measles, rubella, mumps and GMC in the age group of 20 to 29 years old were not high, the positive rate of rubella and mumps was lower than that of the age group of 20 to 29 years old, and the positive rate of rubella antibody was 36.509% and 5.575% P0.05, and the positive rate of measles, rubella and mumps antibody was not high in the low age group of 20 to 29 years old. Conclusion the whole population of Zhaoqing City has established a certain immune barrier against measles, rubella and mumps diseases, but it is necessary to strengthen the prevention and inoculation of young children. Children aged 8 to 11 months were vaccinated with measles rubella combined with live attenuated vaccine. Children over 1.5 years old were vaccinated with MMRs of leprosy combined with attenuated live vaccine. It was suggested that women aged 20 to 29 years old should be vaccinated with Mr or MMRs in order to further improve the level of disease prevention in the whole population.
【作者单位】：广东省肇庆市疾病预防控制中心;
【分类号】：R186

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