中国成年男性第一秒用力呼气容积正常参考值的地理分布规律研究

发布时间：2018-06-01 22:13

本文选题：中国 + 第一秒用力呼气容积　；参考：《陕西师范大学》2007年硕士论文

【摘要】： 健康人肺功能正常参考值是医学正常参考值的一个重要指标。肺功能检测是对尘肺病人进行劳动能力鉴定的主要依据之一，也是客观评价接尘工人肺功能损害的主要检测方法，而健康人第一秒用力呼气容积正常参考值是健康人肺功能正常参考值的一个重要指标，，是常用的判断中小气道有无阻塞的指标。第一秒用力呼气容积正常参考值是对疾病进行诊断和防治的基本依据，每个地区、每个医院都必须建立一套第一秒用力呼气容积正常参考值标准。但由于各地地理环境不同，测定的仪器、对象、方法各异，使得各地区第一秒用力呼气容积正常参考值不一致，因此严重影响了临床诊断的准确性。本论文以国家自然科学基金资助项目“中国人肺功能正常参考值与地理因素的关系”(项目号40671005)为依托，以医学地理学理论、肺功能理论、自然地理学理论和数理统计原理为依据，运用计算机手段，主要是SPSS11．5统计软件、Excel数据处理软件、地理信息系统制图软件(MapInfo)，对第一秒用力呼气容积正常参考值与地理因素关系进行了专题化、定量化研究。本论文把数据分为18-40岁中青年和40-65岁中老年两个年龄段，依次对中青年和中老年进行一元线性回归分析、多元线性回归分析、逐步回归分析、非线性回归分析，通过分析可以看出中青年男性第一秒用力呼气容积和中老年男性第一秒用力呼气容积与所选地理因素并非都具有相关性，中青年第一秒用力呼气容积(Y_1)与年平均相对湿度(X_7)相关性极显著，与海拔高度(X_1)、年降水量(X_3)、年日照时数(X_8)相关性显著，中老年第一秒用力呼气容积(Y_2)与年平均气温(X_2)、一月平均气温(X_5)、七月平均气温(X_6)、年平均相对湿度(X_7)之间相关性显著，它们的相关性不是单一的，而是与地理因素的多重相关，运用SPSS 11．5统计软件最后得出一系列的回归方程。并在相关分析的基础上比较得出了两个最优的模型： ①、18-40岁中青年健康成年男性第一秒用力呼气容积正常参考值预测模型： Y_1=1.906+0.026~*X_7 F=11.605，P=0.000＜0.01 Y_1的预测区间为[Y_1-0.519，Y_1+0.519] 0.519为1.96个剩余标准差 ②、40-65岁中老年健康成年男性第一秒用力呼气容积正常参考值预测模型： Y_2=0.958+0.15~*X_4+0.036~*X_5+0.07~*X_6 F=5.894，P=0.009＜0.01 Y_2的预测区间为[Y_2-0.366，Y_2+0.366] 0.366为1.96个剩余标准差选取8个具有代表性的地区，应用以上模型对该地区中青年男性和中老年男性正常参考值进行预测，并将预测值与实测值进行比较，发现中青年男性和中老年男性的预测值与实测值高度一致，无显著性差异，从而说明以上一系列回归模型可以预测某一地区中青年男性和中老年男性正常参考值，为从地理因素入手计算某一地区中青年男性和中老年男性第一秒用力呼气容积正常参考值提供了简便的方法。通过研究中国成年男性第一秒用力呼气容积正常参考值与地理因素的关系，揭示出了中国成年男性第一秒用力呼气容积正常参考值的地理分布规律，对制定中国成年男性第一秒用力呼气容积正常参考值的标准提供了科学依据，将促进医学更快的发展，本论文的研究方法和研究成果将丰富医学地理学的内容。研究具有重要的现实意义。
[Abstract]:Normal reference value of lung function of healthy people is an important index of normal medical reference value. Lung function test is one of the main basis for identifying the ability of pneumoconiosis patients' ability to work. It is also the main method to evaluate the lung function damage of the exposed workers, and the normal reference value of the healthy people for the first second of the force is the healthy person's lung function. An important index of normal reference value is a common indicator of small and medium airway obstruction. The normal reference value of the first second forced expiratory volume is the basic basis for the diagnosis and prevention of the disease. Each area, each hospital must establish a set of normal reference values for the first second forced expiratory volume. The environment is different, the instruments, objects and methods are different. The normal reference value of the forced expiratory volume in the first second of each region is inconsistent, so the accuracy of the clinical diagnosis is seriously affected.
This paper is based on the "relationship between normal reference value of Chinese lung function and geographical factors" (Project No. 40671005) funded by the National Natural Science Foundation of China, based on the theory of medical geography, lung function theory, the theory of natural geography and the principle of mathematical statistics, and using the means of counting computer, mainly SPSS11.5 statistics software, Excel data The processing software, the geographic information system mapping software (MapInfo), has been thematic and quantitative research on the relationship between the normal reference value of the forced expiratory volume of the first second and the geographical factors.
In this paper, the data are divided into two age groups of 18-40 years old and 40-65 years old and middle aged and old age. The linear regression analysis, multiple linear regression analysis, stepwise regression analysis, nonlinear regression analysis are carried out in turn to middle and young people and middle and old age, and the first second forced expiratory volume and the first second of middle-aged and old men can be seen through analysis. The forced expiratory volume was not correlated with the selected geographical factors. The correlation between the first second forced expiratory volume (Y_1) and the annual average relative humidity (X_7) was very significant. The correlation was significant with the altitude (X_1), the annual precipitation (X_3), the annual sunshine hours (X_8), the first second forced expiratory volume (Y_2) and the annual mean temperature (X_2), and one month's average temperature (X_2). The average temperature (X_5), the average temperature in July (X_6) and the annual average relative humidity (X_7) have a significant correlation. Their correlation is not single, but multiple related to the geographical factors. A series of regression equations are obtained by using the SPSS 11.5 statistical software. And on the basis of the correlation analysis, two optimal models are compared.
(1) the normal reference value of forced expiratory volume in the first second of healthy adults aged 18-40 years old was predicted.
Y_1=1.906+0.026~*X_7 F=11.605, P=0.000 < 0.01
The prediction interval of Y_1 is [Y_1-0.519, Y_1+0.519]
0.519 is 1.96 residual standard deviations
(2) the normal reference value of forced expiratory volume in the first second of healthy adults aged 40-65 years old:
Y_2=0.958+0.15~*X_4+0.036~*X_5+0.07~*X_6 F=5.894, P=0.009 < 0.01
The prediction interval of Y_2 is [Y_2-0.366, Y_2+0.366]
0.366 is 1.96 residual standard deviations
8 representative areas were selected to predict the normal reference values of young men and middle-aged men in the region, and the predicted values were compared with the measured values. It was found that the predicted values of both young and middle-aged men were in good agreement with the measured values, and there was no significant difference, which explained the above regression models. The normal reference value of young male and middle-aged men in a certain area can be predicted, which provides a simple method for calculating the normal reference value of the first second forced expiratory volume of young men and middle aged and old men in a certain area from geographical factors.
By studying the relationship between the normal reference value of the forced expiratory volume in the first second of Chinese adult male and the geographical factors, the geographical distribution law of the normal reference value of the first second forced expiratory volume of the Chinese adult male was revealed, and the scientific basis was provided for the standard of formulating the normal reference value of the first second forced expiratory volume in Chinese adult male. With the rapid development of medicine, the research methods and research results of this paper will enrich the contents of medical geography.
【学位授予单位】：陕西师范大学
【学位级别】：硕士
【学位授予年份】：2007
【分类号】：R188

【引证文献】