河南省开封市儿童医院就诊患儿与健康儿童麻疹抗体水平调查

发布时间：2018-06-18 06:28

本文选题：麻疹 + 抗体　；参考：《中国疫苗和免疫》2017年01期

【摘要】：目的比较分析河南省开封市儿童医院就诊患儿和健康儿童麻疹抗体水平,为制定麻疹院内传播防控策略提供依据。方法采用酶联免疫吸附试验(ELISA)对开封市儿童医院0-4岁就诊患儿和健康儿童进行麻疹IgG抗体水平血清学检测,并进行流行病学分析。结果 812名0-4岁患儿麻疹抗体阳性率为48.28%,抗体几何平均浓度(GMC)为103.02 IU/L;其中517名0-7月龄患儿抗体阳性率和GMC分别为42.75%、86.99 IU/L;295名8月龄-4岁患儿抗体阳性率和GMC分别为57.97%、138.57 IU/L(χ~2=17.42,P0.001;t=2.54,P=0.01)。165名8月龄-4岁健康儿童抗体阳性率和GMC分别为96.36%、920.71 IU/L,高于同年龄患儿(χ~2=76.95,P0.001;t=8.62,P0.001)。8月龄-4岁患儿含麻疹成分疫苗(MCV)接种率为78.64%,低于同年龄健康儿童的99.39%;接种过MCV的患儿或健康儿童抗体阳性率和GMC均高于未种患儿或健康儿童。结论开封市儿童医院就诊患儿麻疹抗体水平低,需研究综合性防控措施,提高患儿麻疹免疫水平,防止患儿的麻疹院内感染。
[Abstract]:Objective to compare and analyze the measles antibody levels of children and healthy children in Kaifeng Children's Hospital, Henan Province, and to provide basis for the strategy of measles prevention and control in hospital. Methods Elisa Elisa was used to detect the level of measles IgG antibody in children aged 0-4 years and healthy children in Kaifeng Children's Hospital. Results the positive rate of measles antibody in 812 children aged 0-4 years was 48.28, the geometric mean concentration of antibody was 103.02 IUL, and the positive rate of antibody and GMC in 517 children aged 0-7 months were 42.759.The positive rates of antibody and GMC were 57.97 and 138.57, respectively. The positive rate of antibody and GMC of 165 healthy children aged 8 months to 4 years old were 96.36 ~ 920.71 IUL / L respectively, higher than those of children of the same age (蠂 ~ 2 ~ (2 +) 76.95 ~ P ~ (0.001) P _ (0.001) t 8.62P _ 0.001N ~ (8) months old ~ 4 years old with measles vaccine MCV), which was lower than that of healthy children of the same age (78.64%), which was lower than that of healthy children of the same age (99.39%). The positive rate of antibody and GMC in children were higher than those in children without children or healthy children. Conclusion the level of measles antibody in children in Kaifeng Children's Hospital is low. It is necessary to study comprehensive prevention and control measures to improve children's measles immunity level and prevent measles nosocomial infection.
【作者单位】：开封市疾病预防控制中心;河南大学第一附属医院;
【基金】：开封市科技发展计划项目(项目号130332)
【分类号】：R725.1;R186

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