上海市普陀区1剂次水痘疫苗保护效果病例对照研究

发布时间：2018-06-18 16:54

  本文选题：水痘 + 水痘疫苗　； 参考：《中国疫苗和免疫》2017年01期

【摘要】：目的探讨普陀区儿童1剂次水痘疫苗(Varicella vaccine,VarV)接种后的保护效果(Vaccine efficacy,VE)。方法采用1:1配对的病例对照研究,病例来源于中国疾病预防控制信息系统传染病报告系统且居住于普陀区的1-7岁水痘病例,并根据性别、年龄、居住小区作为配比条件,在上海市免疫规划信息系统内随机选择对照,与病例形成配对。结果 100对病例对照纳入分析。病例组、对照组的Var V接种率分别为77%、89%(x~2=17.26,P0.01)。1剂次Var V对水痘的VE为80%(95%CI:32.37%-94.09%)。VarV对≥50个和50个皮损的水痘的VE分别为92.28%(95%CI:76.42%-98.28%)、40.67%(95%CI:0.00%-74.55%)。结论 1剂次Var V对水痘和重症水痘具有良好的VE。建议开展2剂Var V接种,以更好地控制水痘暴发和突破病例。
[Abstract]:Objective to investigate the protective effect of varicella vaccine in Putuo district. Methods A 1:1 matched case-control study was conducted. The cases were collected from the infectious disease reporting system of China's disease prevention and control information system and lived in Putuo district. The chickenpox cases aged 1-7 years were used as the matching condition according to their sex, age and residential area. Random control was selected in the Shanghai Immunization Planning Information system to form a pairing with the cases. Results 100 pairs of case control were included in the analysis. In the case group, the vaccination rates of Var V in the control group were 772895CI鈮，

本文编号：2036174