河南地区2010—2015年特发性膜性肾病流行病学变迁

发布时间：2018-07-04 12:34

  本文选题：特发性膜性肾病 + 流行病学　； 参考：《中国实用内科杂志》2017年07期

【摘要】：目的揭示特发性膜性肾病(IMN)的流行病学变迁,为IMN的防治提供数据支持。方法以2010-01-01—2015-12-31期间在郑州大学第一附属医院肾脏病病理实验室诊断的所有患者为研究对象,设计调查表,收集患者的人口学资料、临床化验、病理等相关资料,分析IMN的构成比和变迁。结果共纳入19 172例肾活检标本,其中原发性肾小球病13 147例(68.57%),继发肾小球病5355例(27.93%)例。本研究共筛选出IMN 3679例,男性占53.8%,女性占46.2%。平均年龄(47.61±14.78)岁,男性平均年龄高于女性[(48.69±14.75)岁对(46.38±14.73)岁,P0.05]。进一步以年龄分层分析显示,18岁以下IMN患者所占比例自2012年呈上升趋势。IMN占肾活检总例数比例为19.2%,2010-2015年IMN所占比例亦呈逐年增加趋势(P0.05)。2010-2015年IMN在原发性肾小球病中所占比例亦呈逐年上升趋势,所占比例依次为209例(14.5%)、336例(16.8%)、486例(22.6%)、666例(29.4%)、867例(34.4%)、1115例(40.4%)。结论特发性膜性肾病患病率近年来逐年攀升,并呈年轻化趋势,其机制仍需进一步探讨。
[Abstract]:Objective to investigate the epidemiological changes of idiopathic membranous nephropathy (IMN) and provide data for the prevention and treatment of IMN. Methods all the patients who were diagnosed in the laboratory of renal pathology in the first affiliated Hospital of Zhengzhou University during 2010-01-01-2015-12-31 were selected as the research objects. The questionnaire was designed to collect the demographic data, clinical tests and pathological data of the patients. The composition ratio and transition of IMN are analyzed. Results A total of 19 172 renal biopsy specimens were included, including 13 147 cases (68. 57%) of primary glomerulopathy and 5355 cases (27. 93%) of secondary glomerulopathy. A total of 3679 cases of IMNs were selected in this study, male 53.8% and female 46.2%. The mean age was (47.61 卤14.78) years old, the average age of males was higher than that of females [(48.69 卤14.75) years vs (46.38 卤14.73) years old, P0.05]. Further age stratification analysis showed that the proportion of IMN patients under 18 years of age had been on the rise since 2012. The proportion of IMN to total renal biopsy cases was 19.2and the proportion of IMN from 2010 to 2015 was also increasing year by year (P0.05) .IMN in primary glomerulopathy from 2010 to 2015. The proportion also shows an upward trend year by year. The proportion was 209 cases (14.5%), 336 cases (16.8%), 486 cases (22.6%), 666 cases (29.4%), 867 cases (34.4%), 1115 cases (40.4%). Conclusion the prevalence rate of idiopathic membranous nephropathy has been increasing in recent years and showing a trend of rejuvenation. The mechanism of idiopathic membranous nephropathy needs to be further explored.
【作者单位】： 郑州大学第一附属医院肾脏病中心郑州大学肾脏病研究所;
【基金】：河南省自然科学基金面上项目(162300410282)
【分类号】：R181.3;R692
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本文编号：2096098