湖南湘潭地区育龄妇女人微小病毒B19流行病学调查

发布时间：2018-07-27 10:05

【摘要】：目的了解湖南省湘潭地区育龄妇女人微小病毒B19(HPVB19)感染状况及特点,并探讨不良妊娠结局与妊娠期HPV B19感染的关系。方法采集湘潭地区育龄妇女静脉血,用酶联免疫吸附法检测2011-2012年湘潭地区育龄妇女血清B19-IgM抗体,PCR法检测HPV B19抗体阳性的妇女DNA的表达情况。比较不良妊娠结局、妊娠和婚检妇女的感染率。并进一步进行随访调查,分析不良妊娠结局与B19感染的相关性。结果 5 065例育龄妇女,B19感染率为12.62%,不良妊娠结局组、妊娠组和婚检组感染率分别为18.59%,11.12%和10.55%,不良妊娠结局组和其他两组感染率差异有统计学意义(P0.01);感染组与非感染组不良妊娠结局发生率差异有统计学意义(P0.01)。结论妊娠期HPV B19感染是引起不良妊娠结局的重要原因之一。湘潭地区育龄妇女HPV B19感染率较高,应加强育龄妇女HPV B19感染监测。
[Abstract]:Objective to investigate the status and characteristics of human parvovirus B19 (HPVB19) infection among women of childbearing age in Xiangtan, Hunan Province, and to explore the relationship between adverse pregnancy outcome and HPV B19 infection during pregnancy. Methods the venous blood samples of women of reproductive age in Xiangtan area were collected, and the expression of DNA in the women with positive HPV B19 antibody was detected by enzyme-linked immunosorbent assay (Elisa) in serum of women of reproductive age in Xiangtan area from 2011 to 2012. Rates of infection in women with poor pregnancy outcomes, pregnancy and premarital examinations were compared. Further follow-up investigation was carried out to analyze the relationship between adverse pregnancy outcome and B 19 infection. Results the infection rate of B19 in 5 065 women of childbearing age was 12.62%. The infection rate of pregnancy group and premarital examination group were 18.599.12% and 10.55%, respectively. There was significant difference between the bad pregnancy outcome group and the other two groups (P0.01), and there was significant difference between the infection group and the non-infection group (P0.01). Conclusion infection of HPV B 19 during pregnancy is one of the important causes of adverse pregnancy outcome. The infection rate of HPV B 19 was higher in women of reproductive age in Xiangtan area. The surveillance of HPV B 19 infection among women of reproductive age should be strengthened.
【作者单位】：湘潭职业技术学院;湘潭市中心医院;
【基金】：湘潭市科技局立项课题(ZJ20121008)
【分类号】：R181.3

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