硒蛋白S基因多态性与内蒙古汉族人群胃癌发病风险的关联研究

发布时间：2018-07-28 13:29

【摘要】：目的探讨内蒙古汉族人群硒蛋白S(SelS)基因单核苷酸多态性(SNP)与胃癌发病风险的关联性。方法采用PCR-RFLP技术对133例内蒙古汉族胃癌患者及135例体检健康对照者进行SelS基因分型,并经测序验证结果。采用SPSS17.0分析SelS基因SNP rs34713741与胃癌发病风险的相关性。结果 SelS基因SNP rs34713741基因型CC、CT、TT及等位基因C、T在胃癌组和健康对照组间差异有统计学意义(分别为6.105、6.294,P均0.05)。内蒙古汉族人群中携带T等位基因的CT/TT个体患胃癌的风险是CC基因型个体的1.57倍(OR=1.570,95%CI:1.084~2.274);携带T等位基因且吸烟的个体患胃癌的风险增加,是CC基因型的2.216倍(OR=2.216,95%CI:1.530~3.209)。结论 SelS基因SNP rs34713741与内蒙古汉族人群胃癌的发病具有相关性,T等位基因可能是胃癌发病的危险因素之一,吸烟可增加发病的风险。
[Abstract]:Objective to investigate the association between single nucleotide polymorphisms (SNP) of selenoprotein S (SelS) gene and the risk of gastric cancer in Inner Mongolia Han population. Methods SelS genotyping was performed in 133 patients with gastric cancer of Han nationality in Inner Mongolia and 135 healthy controls by PCR-RFLP, and the results were verified by sequencing. SPSS17.0 was used to analyze the relationship between SelS gene SNP rs34713741 and the risk of gastric cancer. Results there were significant differences in SelS SNP rs34713741 genotype and allele CTT between gastric cancer group and healthy control group (P < 0. 05). CT/TT individuals with T allele were 1.57 times more likely to develop gastric cancer than those with CC genotype (OR1. 570 / 95 CI: 1.084: 2. 274), and those with T allele and smoking were 2.216 times more likely to develop gastric cancer than those with CC genotype (OR2. 216C95 CIW 1.5303.209). Conclusion SelS gene SNP rs34713741 may be one of the risk factors of gastric cancer, and smoking may increase the risk of gastric cancer.
【作者单位】：包头医学院医学技术学院;包头市肿瘤医院;包头医学院第二附属医院;内蒙古自治区人民医院;
【基金】：内蒙古自治区自然科学基金面上项目(2015MS0812)
【分类号】：R181.3;R735.2

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