产妇与婴儿脊髓灰质炎中和抗体水平变化特征分析
发布时间：2018-08-02 20:49
【摘要】：目的评价脊髓灰质炎中和抗体在产妇及其婴儿体内消长规律,比较不同免疫程序下婴儿抗体水平变化。方法选取2013年7月—2014年4月在广州市荔湾区妇幼保健院进行分娩的产妇及其新生儿作为研究对象,采用血清流行病学方法对产妇及产妇所生婴儿0(新生儿)、3、6月龄脊灰中和抗体水平进行分析;并根据婴儿基础免疫程序将其分为脊髓灰质炎减毒活疫苗(OPV)组、脊髓灰质炎灭活疫苗(IPV)与IPV+OPV 3组,比较疫苗接种后的抗体水平。结果共采集179位产妇外周静脉血,婴儿0、3、6月龄时分别采血176、149、62份。新生儿较产妇I、II、III型脊灰中和抗体水平有所下降,3、6月龄时抗体水平均大幅上升,6月龄时各型分别高达607.0(95%CI=146.0~2 523.1)、239.6(95%CI=80.4~713.6)和235.9(95%CI=56.0~994.8)。OPV、IPV、IPV+OPV组在婴儿各个时间段脊灰I、II、III型抗体几何平均滴度倒数(GMRT)和抗体阳性率差异均无统计学意义(均P0.05)。产妇脊灰抗体水平与新生儿脊灰Ⅱ、III型母传抗体呈显著正相关关系(tII=5.953、P=0.000,tIII=7.260、P0.001)。结论新生儿脊灰胎传抗体水平较母体下降。IPV全程接种、IPV与OPV序贯免疫对婴儿均有较好的免疫原性,中国现阶段可大力推进IPV与OPV序贯免疫程序。
[Abstract]:Objective to evaluate the changes of neutralizing antibodies against poliomyelitis in puerpera and their infants, and to compare the changes of antibody levels in infants with different immune procedures. Methods from July 2013 to April 2014, the pregnant women and their newborns in Liwan District Maternal and Child Health Hospital of Guangzhou City were selected as the research objects. Seroepidemiological method was used to analyze the level of neutralizing antibody against poliomyelitis of puerpera and their newborn infants at the age of 3 months and 6 months, and to divide them into two groups according to the basic immune program of infants: (OPV) group with attenuated live poliomyelitis vaccine. The antibody levels of inactivated poliomyelitis vaccine (IPV) and IPV OPV were compared. Results Peripheral venous blood was collected from 179 puerperas. The level of neutralizing antibody against poliomyelitis type III in newborns was lower than that in puerpera. The level of antibody increased significantly at the age of 3 to 6 months. At the age of 6 months, the antibody levels were as high as 607.0 (95%CI=146.0~2 523.1) / 239.6 (95%CI=80.4~713.6) and 235.9 (95%CI=56.0~994.8) .OPVV IPV / IPV OPV respectively. The geometric mean titers of II-IIIII antibody were inverted in the infants at all time periods. The number of (GMRT) and antibody positive rate were not significantly different (P0.05). The level of poliomyelitis antibody in puerpera was positively correlated with the maternal antibody of type 鈪，
本文编号：2160691
[Abstract]:Objective to evaluate the changes of neutralizing antibodies against poliomyelitis in puerpera and their infants, and to compare the changes of antibody levels in infants with different immune procedures. Methods from July 2013 to April 2014, the pregnant women and their newborns in Liwan District Maternal and Child Health Hospital of Guangzhou City were selected as the research objects. Seroepidemiological method was used to analyze the level of neutralizing antibody against poliomyelitis of puerpera and their newborn infants at the age of 3 months and 6 months, and to divide them into two groups according to the basic immune program of infants: (OPV) group with attenuated live poliomyelitis vaccine. The antibody levels of inactivated poliomyelitis vaccine (IPV) and IPV OPV were compared. Results Peripheral venous blood was collected from 179 puerperas. The level of neutralizing antibody against poliomyelitis type III in newborns was lower than that in puerpera. The level of antibody increased significantly at the age of 3 to 6 months. At the age of 6 months, the antibody levels were as high as 607.0 (95%CI=146.0~2 523.1) / 239.6 (95%CI=80.4~713.6) and 235.9 (95%CI=56.0~994.8) .OPVV IPV / IPV OPV respectively. The geometric mean titers of II-IIIII antibody were inverted in the infants at all time periods. The number of (GMRT) and antibody positive rate were not significantly different (P0.05). The level of poliomyelitis antibody in puerpera was positively correlated with the maternal antibody of type 鈪，
本文编号：2160691
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