IL-6基因单核苷酸多态性与系统性红斑狼疮的相关性研究

发布时间：2018-08-04 10:24

【摘要】：目的探讨白细胞介素(interleukin,IL)6单核苷酸多态性(single nucleotide polymorphism,SNP)(rs1800796)与系统性红斑狼疮(systemic lupus erythematosus,SLE)的易感性。方法选取SLE患者666例作为病例组,年龄、性别匹配的569例正常人作为对照组,采用TaqMan基因分型技术检测rs1800796基因型频率。结果 Rs1800796 SNP的基因型(CC,CG和GG)频率和等位基因(C和G)频率在SLE患者和对照间差异均无统计学意义(均有P0.05)。Rs1800796与SLE临床表现的关联性分析发现,C等位基因频率在伴有浆膜炎的SLE患者中低于不伴有浆膜炎的SLE患者(P=0.019)。但C等位基因频率的分布在是否表现有颧部红斑、盘状红斑、光敏感、口腔溃疡、关节炎及狼疮肾炎的SLE病人间差异均无统计学意义(均有P0.05)。结论尚未发现IL-6rs1800796在中国汉族人群与SLE遗传易感性有关。Rs1800796 C等位基因可能对SLE病人并发浆膜炎起保护作用。
[Abstract]:Objective to investigate the susceptibility of interleukin 6 (IL 6) (single nucleotide polymorphisms (rs1800796) to (systemic lupus erythematosus (SLE) in patients with systemic lupus erythematosus (SLE). Methods 666 patients with SLE were selected as case group and 569 normal subjects matched with age and sex as control group. TaqMan genotyping technique was used to detect the frequency of rs1800796 genotypes. Results the frequency of genotype (CCG and GG) and allele (C and G) of Rs1800796 SNP had no significant difference between SLE patients and controls (P0.05) .Rs1800796 was associated with the clinical manifestations of SLE. The incidence of SLE was lower in SLE patients than in SLE patients without serositis (P0. 019). But the distribution of C allele frequency in whether there were zygomatic erythema, disc erythema, light sensitivity, oral ulcer, arthritis and lupus nephritis among SLE patients there was no significant difference (P0.05). Conclusion the allele Rs1800796C related to the genetic susceptibility of IL-6rs1800796 in Chinese Han population may play a protective role in serositis in SLE patients.
【作者单位】：安徽医科大学公共卫生学院流行病与卫生统计学系;
【基金】：国家自然科学基金(81172764)
【分类号】：R593.241;R181.26

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