接种国产酵母型免费乙肝疫苗后1～8岁儿童乙肝免疫效果调查分析
发布时间：2018-08-11 15:01
【摘要】：目的为了解接种了3针乙肝疫苗后1~8岁儿童人群乙肝抗-HBs滴度及阳性率变化情况及影响因素,为制定国家免疫规划政策提供依据。方法采取整群随机抽样方法采集四川省绵阳市涪城区仅接受了国家3针免费乙肝疫苗接种的城乡儿童血清,采用双抗原夹心时间分辨免疫荧光分析法(IFMA法)对乙肝表面抗体(抗-HBs)定量检测,采用χ~2检验和方差分析进行差异比较。结果本次共调查了符合条件的807名儿童,乙肝抗-HBs阳性率为61.7%。儿童人群乙肝抗-HBs滴度和阳性率在接种后3年内下降最快,4-6岁波动较大,6岁后回升到一定水平;乙肝抗-HBs滴度和阳性率与性别、城乡差异无统计学意义。结论已全程接种3针乙肝疫苗的儿童人群应每间隔3年进行1次乙肝血清标志物检测,对乙肝抗-HBs阴性或滴度≤10mIU/ml者及时进行加强免疫。
[Abstract]:Objective to investigate the changes of hepatitis B anti-HBs titer and positive rate in children aged 1 to 8 years after three doses of hepatitis B vaccine, and to provide evidence for the formulation of national immunization planning policy. Methods A cluster random sampling method was used to collect serum samples from urban and rural children in Fucheng District, Mianyang City, Sichuan Province, who received only 3 doses of free hepatitis B vaccine. Double antigen sandwich time resolved immunofluorescence assay (IFMA) was used to detect hepatitis B surface antibody (anti-HBs) quantitatively, 蠂 ~ 2 test and variance analysis were used to compare the difference. Results the positive rate of anti-HBs was 61.7 in 807 children. The titer and positive rate of anti-HBs in children decreased the fastest within 3 years after inoculation and increased to a certain level after 6 years old, but the titer and positive rate of anti-HBs were no significant difference between urban and rural areas. Conclusion the serum markers of hepatitis B should be detected once every 3 years in children who have been vaccinated with 3 doses of hepatitis B vaccine during the whole course, and the patients with anti-HBs negative or titer 鈮，
本文编号：2177339
[Abstract]:Objective to investigate the changes of hepatitis B anti-HBs titer and positive rate in children aged 1 to 8 years after three doses of hepatitis B vaccine, and to provide evidence for the formulation of national immunization planning policy. Methods A cluster random sampling method was used to collect serum samples from urban and rural children in Fucheng District, Mianyang City, Sichuan Province, who received only 3 doses of free hepatitis B vaccine. Double antigen sandwich time resolved immunofluorescence assay (IFMA) was used to detect hepatitis B surface antibody (anti-HBs) quantitatively, 蠂 ~ 2 test and variance analysis were used to compare the difference. Results the positive rate of anti-HBs was 61.7 in 807 children. The titer and positive rate of anti-HBs in children decreased the fastest within 3 years after inoculation and increased to a certain level after 6 years old, but the titer and positive rate of anti-HBs were no significant difference between urban and rural areas. Conclusion the serum markers of hepatitis B should be detected once every 3 years in children who have been vaccinated with 3 doses of hepatitis B vaccine during the whole course, and the patients with anti-HBs negative or titer 鈮，
本文编号：2177339
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