某医院SARS爆发流行特点及血清流行病学研究

发布时间：2018-09-10 07:05

【摘要】：严重急性呼吸道综合征(Severe Acute Respiratory Syndrome,SARS)是新出现的一种人类传染病,2003年4月15日,天津某医院一例输入性病例引发了该医院SARS爆发流行。利用该医院爆发流行现场,调查和研究SARS医院内爆发流行的特点;研究SARS患者康复期血清冠状病毒抗体变化规律;了解疫区内人群血清SARS冠状病毒抗体水平以及是否存在隐性感染。目的:通过医院内SARS爆发疫情的描述性研究,了解医院内SARS爆发流行的特点、规律,同时评价院内感染控制措施的效果;通过SARS爆发流行疫源地血清流行病学研究,动态观察SARS人群康复后不同时间血清冠状病毒抗体变化规律,观察疫情前后非SARS人群SARS冠状病毒IgG抗体免疫水平,阐明SARS人群血清冠状病毒抗体变化规律,SARS是否存在隐性感染等,为SARS诊断和预防与控制提供理论依据。方法:采用描述性流行病学方法研究医院内SARS爆发流行的特点、规律;采用前瞻性流行病学研究的方法研究SARS疫源地血清流行病学特点。结果: 1 医院内SARS爆发的描述性研究结果显示: (1)一例输入性传染源引发了该医院的SARS疫情,由于早期缺乏防护意识和有效防控措施导致了SARS疫情在医院内的传播、蔓延;(2)此次医院内SARS爆发流行发生三代病例,累计88例,被感染者发病时间集中在疫情出现后的第4到第8天(4月20日-4月24日),人群分布特点表现为女性多于男性,年龄集中在20-45岁,医院工作人员中护士和医生感染比例较高;在科室分布上,感染者集中在指示病例所在科室,并以此为中心,向四周科室和部门辐射;电
[Abstract]:Severe Acute Respiratory Syndrome (Severe Acute Respiratory Syndrome,SARS) is a new human infectious disease. On April 15, 2003, an imported case caused the outbreak of SARS in Tianjin Hospital. To investigate and study the characteristics of epidemic outbreak in SARS hospital, to investigate the changes of serum coronavirus antibodies in patients with SARS during convalescence. To know the level of serum SARS coronavirus antibody and whether there is recessive infection. Objective: to understand the characteristics and regularity of SARS outbreak in hospital, to evaluate the effect of nosocomial infection control measures, and to study the seroepidemiology of SARS epidemic foci by means of descriptive study on the outbreak of SARS in hospital. The changes of serum coronavirus antibody and the immune level of SARS coronavirus IgG antibody were observed at different time after rehabilitation in SARS population. To elucidate the changes of serum coronavirus antibodies in SARS population and to provide theoretical basis for the diagnosis, prevention and control of SARS. Methods: descriptive epidemiological method was used to study the characteristics and regularity of SARS outbreak in hospitals, and prospective epidemiological study was used to study the seroepidemiological characteristics of SARS foci. Results: 1 descriptive study of SARS outbreak in hospital showed that: (1) an imported source of infection caused the SARS epidemic in the hospital. The early lack of awareness of protection and effective prevention and control measures led to the spread and spread of SARS in hospitals. (2) there were three generations of SARS outbreaks in hospitals, a total of 88 cases. The incidence time of the infected patients was from the 4th to the 8th day (April 20-April 24). The distribution of the population was more female than male, the age was 20-45 years old, the proportion of nurses and doctors infection was higher in hospital staff. In the distribution of departments, the infected people concentrated in the department where the indicative case is located, and this as the center, radiation to the four departments and departments; electricity;
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R181.3

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