河南省2012年成人乙型病毒性肝炎血清流行病学调查

发布时间：2018-10-26 10:45

【摘要】：目的:了解河南省成人乙型病毒性肝炎(简称乙肝)流行现状,分析成人乙肝病毒(HBV)感染的血清流行病学变化趋势。方法:采用分层整群随机抽样方法抽取样本,对河南省30个县区15~74岁人群共17 986人进行了问卷调查和采血,采用ELISA方法对血样进行HBV血清学指标的检验,对于阳性标本采用另一种试剂盒复检,复检结果与初检不一致的用全自动微粒子酶免分析仪确定。对HBsAg检测结果为阳性的对象按照1∶3选择对照,分析HBV感染的风险因素。结果:河南省2012年成人的HBV感染率为45.29%,HBsAg阳性率为3.99%,抗-HBc阳性率为44.95%,抗-HBs阳性率为45.16%;其中15~岁年龄组HBsAg阳性率最低,为3.04%,55~74岁年龄组HBsAg阳性率最高,为4.97%;15~岁年龄组抗-HBs阳性率最高,为46.08%,55~74岁年龄组抗-HBs阳性率最低,为10.15%。不同的血清学指标与年龄呈现不同的曲线关系,HBsAg阳性率和抗-HBc阳性率随年龄升高而升高。多因素分析结果表明,家庭成员长期一起生活是主要的传播方式。结论:河南省成人HBV感染率有缓慢下降趋势。
[Abstract]:Objective: to investigate the prevalence of adult hepatitis B virus (HBV) in Henan province and analyze the seroepidemiological trend of adult hepatitis B virus (HBV) infection. Methods: using stratified cluster random sampling method, 17 986 people aged 1574 years old in 30 counties and districts of Henan Province were investigated by questionnaire and blood samples were collected. ELISA method was used to test the HBV serological indexes. Another kit was used for the reexamination of positive samples. The results of the reexamination were determined by the automatic microparticle enzyme immunoassay. The risk factors of HBV infection were analyzed according to 1:3 selection control for HBsAg positive subjects. Results: the positive rate of HBV, anti HBc, anti HBs and anti HBs were 45.29, 44.95, 44.95 and 45.16, respectively, in Henan province in 2012. The positive rates of HBV were 3.99, 44.95 and 45.16, respectively. The positive rate of HBsAg was the lowest in the 15-year-old group, and the highest in the age group of 3.04 ~ 5574 (4.97%). The positive rate of anti-HBs was the highest in the age group of 15 ~ 74 years old, and the lowest positive rate of anti-HBs was 10. 15% in the age group of 45. 08 and 55. 74 years old. The positive rate of HBsAg and anti-HBc increased with age. Multivariate analysis showed that long-term family members living together was the main mode of transmission. Conclusion: adult HBV infection rate in Henan Province is decreasing slowly.
【作者单位】：河南省疾病预防控制中心免疫规划所;
【分类号】：R181.3

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