青海省孕妇乙型病毒性肝炎产前筛查及母婴传播阻断现况调查
发布时间：2018-11-12 11:54
【摘要】：目的评价青海省孕产妇产前乙型肝炎(乙肝)病毒(HBV)标志物筛查及母婴传播阻断开展情况。方法在全省城市、农村和牧区各选择2个县(区)对14家医院的孕妇HBV标志物筛查和乙肝母婴传播阻断工作开展调查和分析,对首剂乙肝疫苗(HepB1)的未及时接种原因进行分析。结果共调查孕妇9 915名,HBV筛查率为97.75%,HBV表面抗原(HBsAg)阳性率为3.56%;9 848名住院分娩新生儿HepB1及时接种率为96.50%(9 503/9 848);345名HBsAg阳性母亲新生儿HepB1与乙肝免疫球蛋白(HBIG)联合接种率为98.55%(340/345)。上述各指标在城市、农村、牧区之间均无显著性差异。在416名未及时接种HepB1儿童中,56.97%为早产/出生低体重,30.77%为新生儿窒息,7.69%为新生儿黄疸,4.57%为家长拒绝接种。结论青海省孕产妇产前HBV标志物筛查和母婴传播阻断工作能够有效开展。需加强农村和牧区的措施落实,对医护人员需加强培训指导,合理掌握HepB禁忌证,加强早产儿/低体重儿HepB1接种。
[Abstract]:Objective to evaluate the screening of prenatal hepatitis B virus (HBV) (HBV) markers and the interruption of mother-to-child transmission in pregnant women in Qinghai province. Methods two counties (districts) were selected in cities, rural areas and pastoral areas in the province to investigate and analyze the screening of maternal HBV markers and the interruption of mother-to-child transmission of hepatitis B in 14 hospitals. The causes of untimely vaccination of first dose hepatitis B vaccine (HepB1) were analyzed. Results A total of 9 915 pregnant women were investigated, and the positive rate of HBV screening was 97.75%. The positive rate of HepB1 in 9 848 hospitalized neonates was 96.50% (9 503 / 9 848). The combined vaccination rate of HepB1 and HBV immunoglobulin (HBIG) in newborns of 345 mothers with HBsAg positive was 98.55% (340 / 345). There was no significant difference among the above indexes in urban, rural and pastoral areas. 56.97% were premature birth / low birth weight, 30.77% were neonatal asphyxia, 7.69% were neonatal jaundice, and 4.57% were parents who refused to inoculate. Conclusion Prenatal screening of HBV markers and blocking of mother-to-child transmission can be carried out effectively in pregnant women in Qinghai province. It is necessary to strengthen the implementation of measures in rural and pastoral areas, strengthen training and guidance for medical personnel, reasonably master the contraindications of HepB, and strengthen HepB1 vaccination for premature infants / low birth weight infants.
【作者单位】： 青海省疾病预防控制中心;中国疾病预防控制中心;
【分类号】：R186
本文编号：2327040
[Abstract]:Objective to evaluate the screening of prenatal hepatitis B virus (HBV) (HBV) markers and the interruption of mother-to-child transmission in pregnant women in Qinghai province. Methods two counties (districts) were selected in cities, rural areas and pastoral areas in the province to investigate and analyze the screening of maternal HBV markers and the interruption of mother-to-child transmission of hepatitis B in 14 hospitals. The causes of untimely vaccination of first dose hepatitis B vaccine (HepB1) were analyzed. Results A total of 9 915 pregnant women were investigated, and the positive rate of HBV screening was 97.75%. The positive rate of HepB1 in 9 848 hospitalized neonates was 96.50% (9 503 / 9 848). The combined vaccination rate of HepB1 and HBV immunoglobulin (HBIG) in newborns of 345 mothers with HBsAg positive was 98.55% (340 / 345). There was no significant difference among the above indexes in urban, rural and pastoral areas. 56.97% were premature birth / low birth weight, 30.77% were neonatal asphyxia, 7.69% were neonatal jaundice, and 4.57% were parents who refused to inoculate. Conclusion Prenatal screening of HBV markers and blocking of mother-to-child transmission can be carried out effectively in pregnant women in Qinghai province. It is necessary to strengthen the implementation of measures in rural and pastoral areas, strengthen training and guidance for medical personnel, reasonably master the contraindications of HepB, and strengthen HepB1 vaccination for premature infants / low birth weight infants.
【作者单位】： 青海省疾病预防控制中心;中国疾病预防控制中心;
【分类号】：R186
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