福建省沿海地区居民PG、G-17及H.pylori抗体血清流行病学调查
发布时间：2018-11-15 20:25
【摘要】：目的研究血清胃蛋白酶原(Pepsinogen,PG)、胃泌素-17(Gastrin-17,G-17)和幽门螺杆菌(Helicobacter pylori,H.pylori)抗体在福建省沿海地区居民中的分布特征,探讨这些血清学指标用于该省人群胃癌早期筛查的可能性。方法采用多阶段分层随机抽样方法在长乐江田镇、同安大同镇和福安赛歧镇选择当地居民为调查对象,以ELISA法检测血清PGⅠ、PGⅡ、G-17和H.pylori抗体,用中位数和率描述上述指标的分布特征,并用秩和检验、卡方检验和多重线性回归分析方法进行统计学分析。结果 PGⅠ、PGⅡ、PGⅠ/Ⅱ比值(PGR)、G-17的中位数水平分别为113.75μg/L、12.0μg/L、9.89、1.4 pmol/L,H.pylori感染率为37.1%。男性PGⅠ、PGⅡ水平显著高于女性,PGⅡ随年龄增加而升高,有胃癌家族史居民G-17水平显著高于无家族史者,长乐江田镇H.pylori感染率显著高于其他两地,PGⅠ、PGⅡ、PGR和G-17水平在不同调查地区和H.pylori感染人群中的差异均有统计学意义。结论福建省沿海地区居民血清PGⅠ、PGⅡ、G-17和H.pylori抗体水平在不同性别、年龄、胃癌家族史和调查地区上可能存在差异。
[Abstract]:Objective to study the distribution of serum pepsinogen (Pepsinogen,PG), gastrin-17 (Gastrin-17,G-17) and Helicobacter pylori (Helicobacter pylori,H.pylori) antibodies in the coastal areas of Fujian Province. To explore the possibility of using these serological markers for early gastric cancer screening in the population of the province. Methods using multi-stage stratified random sampling method, the local residents were selected from Changle Jiangtian Town, Tongan Datong Town and Fu'an Seiqi Town. The serum PG 鈪，
本文编号：2334358
[Abstract]:Objective to study the distribution of serum pepsinogen (Pepsinogen,PG), gastrin-17 (Gastrin-17,G-17) and Helicobacter pylori (Helicobacter pylori,H.pylori) antibodies in the coastal areas of Fujian Province. To explore the possibility of using these serological markers for early gastric cancer screening in the population of the province. Methods using multi-stage stratified random sampling method, the local residents were selected from Changle Jiangtian Town, Tongan Datong Town and Fu'an Seiqi Town. The serum PG 鈪，
本文编号：2334358
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