2003-2005年山东省肾综合征出血热宿主变化及流行病学特征的研究

发布时间：2018-11-29 13:56

【摘要】：肾综合征出血热(Haemorrhagic Fever with Renal Syndrome，HFRS)是我国重点防治的传染病之一，其特点是发病急、病情重、病死率高，，严重危害人群的生命和健康。山东省是我国HFRS发病最严重的地区之一，自1984年以来，每年发病人数都位于全国前列。为了有效控制山东省HFRS疫情，本研究根据山东省HFRS人间疫情以及宿主动物的监测结果，采用相关的流行病学、统计学原理和方法，探讨山东省HFRS的变化趋势，为进一步开展HFRS防治工作提供依据。 目的：通过对2003—2005年山东省各市HFRS人间疫情、宿主动物感染情况进行分析，探讨山东省HFRS人间疫情以及汉坦病毒(Hantavirus，HV)宿主动物的变化特点，并通过对山东省莒南县2004年2月—2005年1月连续12个月的鼠情监测，以及山东省莒南县农村人群中HV血清抗体的监测，分析鼠种构成、鼠密度、鼠带病毒率、带病毒鼠指数等指标，掌握鼠情变化情况和人群的血清抗体水平，为控制山东省HFRS的发生和流行，切实有效的提高山东省HFRS防治效率提供理论依据。 方法：山东省2003—2005年HFRS疫情资料，来自山东省疾病预防控制中心，疫情资料为修正后资料。 宿主动物监测，在山东省各市的HFRS监测点用夹夜法、鼠笼法或者粘鼠板法捕鼠，鉴别鼠种，计算鼠密度，无菌条件下采集鼠肺，放在液氮罐或-70℃的冰箱中冷冻保存。鼠肺标本用冷冻切片机切片后，用直接免疫荧光法或者间接免疫荧光法检测鼠肺中是否携带HV。 山东省农村人群中隐性感染情况的调查，用滤纸片采集健康人群的末梢血，晾干后，冷冻保存，用细胞抗原片通过间接免疫荧光法检测血清中的HV抗体。
[Abstract]:Hemorrhagic fever with renal syndrome (Haemorrhagic Fever with Renal Syndrome,HFRS) is one of the most important infectious diseases in China. Shandong Province is one of the most serious HFRS cases in China. In order to effectively control the HFRS epidemic situation in Shandong Province, according to the surveillance results of human HFRS epidemic situation and host animals in Shandong Province, using the relevant epidemiological, statistical principles and methods, the change trend of HFRS in Shandong Province was discussed. To provide the basis for the further development of HFRS prevention and control work. Objective: to analyze the human HFRS epidemic situation and host animal infection in Shandong Province from 2003 to 2005, and to explore the characteristics of HFRS human epidemic situation and Hantavirus (Hantavirus,HV) host animals in Shandong Province. The composition of mouse species, the density of mice and the rate of carrying virus in mice were analyzed by monitoring the rat condition in Junan County, Shandong Province, from February 2004 to January 2005, and by monitoring the serum antibodies against HV in the rural population of Junan County, Shandong Province. In order to control the occurrence and prevalence of HFRS in Shandong Province and effectively improve the efficiency of HFRS prevention and treatment in Shandong Province, the index of virus carrying mice and the level of serum antibody of the population were grasped. Methods: the data of HFRS epidemic in Shandong Province from 2003 to 2005 were collected from the Center for Disease Control and Prevention of Shandong Province. Host animals were monitored. The HFRS monitoring sites in Shandong Province were collected by night-clamping method, cage method or stick plate method to identify rodent species, calculate rat density, collect rat lungs under aseptic conditions, and store them in liquid nitrogen tanks or refrigerators at -70 鈩

本文编号：2365172