地佐辛在小儿阑尾切除术麻醉中的安全性

发布时间：2018-01-06 02:29

  本文关键词：地佐辛在小儿阑尾切除术麻醉中的安全性　出处：《吉林医学》2016年09期 　论文类型：期刊论文

  更多相关文章： 地佐辛 小儿阑尾切除术 麻醉安全性 丙泊酚联合瑞芬太尼全凭静脉麻醉

【摘要】：目的:评价术中地佐辛在小儿阑尾切除术麻醉中的安全性。方法:选择拟行小儿阑尾切除术患儿60例。随机分为地佐辛组(DZX组)和生理盐水组(NS组),每组30例。两组术中输注瑞芬太尼0.2~0.3μg(kg·min)和丙泊酚4~8 mg/(kg·1)维持麻醉。手术开始切皮时,DZX组与NS组分别持续输注0.1 mg/kg地佐辛和生理盐水。记录自主呼吸恢复、呼唤睁眼、拔管时间;苏醒后5 min、30 min、12 h、24 h、48 h疼痛(visual analogue scales,VAS)评分;诱导前(T0),诱导后(T1)、插管后(T2)、术中(T3)、拔管时(T4)、拔管后10 min(T5)平均动脉压(MAP)和心率(HR);术中知晓、苏醒时躁动、静脉滴注曲马多、术后呕心/呕吐、过度镇静和呼吸抑制发生情况。结果:DZX组与NS组自主呼吸恢复、呼唤睁眼及拔管时间无统计学意义(P0.05);DZX组苏醒后5 min、30 min和4 h VAS评分低于NS组(P0.05);在T4、T5时点比较,DZX组MAP和HR低于NS组(P0.05);DZX组苏醒时躁动、疼痛(VAS评分≥3)、术后使用曲马多发生率低于NS组(P0.05)。结论:术中输注地佐辛改善丙泊酚联合瑞芬太尼全凭静脉麻醉下小儿阑尾切除术患儿术后的痛觉过敏。
[Abstract]:Objective: to evaluate the safety of intraoperative dizosin during appendectomy in children. Methods: 60 children undergoing appendectomy were randomly divided into DZX group (n = 60) and saline group (n = 60). Group NS). 30 patients in each group were given remifentanil (0.2 渭 g / kg 路min) and propofol (48 mg/(kg 路min) intraoperatively. DZX group and NS group were continuously infused with dizosin and normal saline for 0.1 mg/kg respectively. The time of spontaneous respiration recovery, eye opening and extubation were recorded. Visual analogue scales scale (VASs) score was obtained 5 min after waking up at 30 min and 12 h at 24 h and 48 h after recovery. The mean arterial pressure (MAPP) and heart rate (HRV) were observed in T0, T1, T2, T3, T4 and T5 during extubation and 10 min after extubation. Intraoperative knowledge, restlessness during recovery, tramadol intravenous drip, postoperative nausea / vomiting, excessive sedation and respiratory inhibition. There was no significant difference in the time of eye opening and extubation (P 0.05). The VAS scores in DZX group were lower than those in NS group at 30 min and 4 h after waking up 5 minutes after recovery (P 0.05). The MAP and HR of DZX group were lower than that of NS group at T4 / T5 time point. In DZX group, the patients were restless and the pain score was 鈮，

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