不同麻醉药对瑞芬太尼诱发术后痛觉超敏的影响

发布时间：2018-01-29 06:15

本文关键词： 瑞芬太尼痛觉超敏丙泊酚七氟烷　出处：《现代生物医学进展》2016年09期 　论文类型：期刊论文

【摘要】：目的:评价不同麻醉药对瑞芬太尼诱发术后痛觉超敏的影响。方法:40只尾静脉置管成功的成年雄性SD大鼠,根据不同麻醉方式随机分为5组(n=8):七氟醚麻醉组(S组);七氟醚+瑞芬太尼复合麻醉组(S+R组);小剂量丙泊酚麻醉组(Pro组);小剂量丙泊酚+瑞芬太尼麻醉组(Pro+R组);大剂量丙泊酚+瑞芬太尼麻醉组(HPro+R组)。在不同麻醉方式下建立大鼠后足切割痛模型并维持麻醉一小时,于术前24小时以及停药后6小时,24小时,48小时测定双后足的机械痛阈(PWT)及观测以上不同时间点切割足的累积疼痛评分(CPS)。结果:S+R组与S组相比,停药后6小时切割足的CPS增加(P0.05)、24小时双后足的PWT均下降(P0.05)。HPro+R在停药后各时间点切割足的PWT均高于Pro组(P0.001)、Pro+R组(P0.01)。与Pro+R组相比,HPro+R组在停药后各时间点切割足的CPS均低于Pro+R组(P0.05)。结论:吸入麻醉药七氟醚可加剧瑞芬太尼导致的术后痛觉过敏,而大剂量丙泊酚可抑制瑞芬太尼诱发的术后痛觉过敏。
[Abstract]:Objective: to evaluate the effect of different anesthetics on postoperative pain hypersensitivity induced by remifentanil. Methods: 40 adult male Sprague-Dawley rats with successful caudal vein catheterization were used. According to different anesthetic methods, they were randomly divided into 5 groups: sevoflurane anesthesia group (group S) and sevoflurane anesthesia group (group S); Sevoflurane remifentanil combined anesthesia group and S R group; Low dose propofol anesthesia group with propofol group; Low dose propofol remifentanil anesthesia group with propofol remifentanil anesthesia group; High dose propofol remifentanil anesthesia group (HPro R) was used to establish the model of hind foot incision pain in rats under different anesthetic methods and maintain anesthesia for one hour, 24 hours before operation and 6 hours after withdrawal. The mechanical pain threshold (PWTs) of both hind feet was measured at 24 h and 48 h, and the cumulative pain score (CPST) was measured at different time points above. Results compared with that of S group, the score of CPSs in the 20% S R group was higher than that in the S group. The CPS of foot cutting increased by P0.05 at 6 hours after discontinuation of the drug. The PWT of both hind feet decreased after 24 hours. The PWT of the cut foot was higher than that of the Pro group at each time point after stopping the drug (P 0. 001). Pro R group was compared with Pro R group. The CPS of HPro R group was lower than that of Pro R group at every time point. Conclusion: inhaled sevoflurane can aggravate postoperative hyperalgesia caused by remifentanil. High dose propofol inhibited postoperative hyperalgesia induced by remifentanil.
【作者单位】：中南大学湘雅二医院麻醉科;
【基金】：湖南省社会发展支撑计划(2014SK3112)
【分类号】：R614
【正文快照】： Chinese Library Classification(CLC):Q95-3;R614 Document code:AArticle ID:1673-6273(2016)09-1615-04前言瑞芬太尼是一种人工合成的新型超短效阿片类镇痛药,因其具有起效快、作用时间短、清除迅速、重复应用和持续输注无蓄积等优点,被誉为二十一世纪的阿片类药物[1]。随

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