低剂量盐酸戊乙奎醚对老年食管癌根除术患者腺体分泌及早期认知影响分析

发布时间：2018-02-02 14:08

本文关键词： 老年食管癌低剂量盐酸戊乙奎醚腺体分泌术后认知功能障碍　出处：《重庆医学》2015年08期 　论文类型：期刊论文

【摘要】：目的探讨低剂量盐酸戊乙奎醚对老年食管癌根除术患者腺体分泌及早期认知的影响。方法 146例择期行食管癌根除术老年患者随机分成低剂量组和高剂量组,每组73例,麻醉前30min,两组患者分别采用0.005mg/kg和0.015mg/kg盐酸戊乙奎醚进行静脉注射。记录两组患者手术情况及术后认知功能障碍(POCD)发生情况,应用视觉模拟评分法(VAS)对口干情况进行评价,利用简易智力状况检查法(MMES)定量评估患者认知能力。结果低剂量组患者术后POCD发生率远低于高剂量组,差异有统计学意义(P0.05),气道分泌物多于高剂量组,差异有统计学意义(P0.05);与术前比较,两组患者T1~4时刻患者口干评分均明显升高,差异均有统计学意义(P0.05),T1~4时刻,低剂量组患者口干评分均低于高剂量组,差异均有统计学意义(P0.05);T5和T6时刻,低剂量组患者MMES评分均高于高剂量组,差异均有统计学意义(P0.05)。结论低剂量盐酸戊乙奎醚应用于老年食管癌根除术患者可以抑制腺体分泌,减少术后早期POCD发生,较为安全有效。
[Abstract]:Objective to evaluate the effect of low dose of penehyclidine hydrochloride and the effect of eradication of early postoperative cognitive glands on the secretion of elderly patients with esophageal carcinoma. Methods 146 patients scheduled for esophageal cancer radical resection in elderly patients were randomly divided into low dose group and high dose group, 73 cases in each group, 30min before anesthesia, two groups of patients were collected for intravenous injection and 0.005mg/kg 0.015mg/kg penehyclidine hydrochloride. Two groups were recorded in operation and postoperative cognitive dysfunction (POCD) occurrence, using visual analogue scale (VAS) to evaluate the dry mouth, using the mini mental state examination (MMES). The results of quantitative assessment of cognitive ability in patients with low dose group of patients after POCD were more lower than the high dose group, the difference was statistically significant (P0.05), airway secretions than high dose group, the difference was statistically significant (P0.05); compared with the preoperative, two groups of patients with T1~4 patients with dry mouth moment scores significantly rise High, the differences were statistically significant (P0.05, T1~4), low dose group of patients with xerostomia scores were lower than the high dose group, the differences were statistically significant (P0.05); T5 and T6, the low dose group of MMES patients were higher than that of the high dose group, the differences were statistically significant (P0.05). Conclusion: low dose of amyl ethyl hydrochloride penehyclidine used in elderly esophageal cancer patients with eradication can inhibit glandular secretion, reduce early postoperative POCD, is safe and effective.

【作者单位】：河南省新乡市中心医院麻醉科;
【分类号】：R735.1
【正文快照】： 老年食管癌根除术患者早期易发生术后认知功能障碍(postoperative cognitive dysfunction,POCD),发生POCD则会大大增加患者术后病死率[1-2],因此,如何有效减少POCD的发生已成为临床研究的重点。有研究指出[3],中枢神经乙酰胆碱衰退可能与老年POCD发生有关。盐酸戊乙奎醚是中国

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