引入地西泮对速眠新复合氯胺酮麻醉效果的改进观察

发布时间：2018-02-06 00:10

本文关键词： 麻醉速眠新氯胺酮地西泮兔　出处：《中国比较医学杂志》2015年01期 　论文类型：期刊论文

【摘要】：目的改进速眠新单纯与复合麻醉方法的不足,观察引入地西泮对速眠新复合盐酸氯胺酮麻醉效果的影响。方法成年实验家兔80只,雌雄各半,随机分为A、B、C三组,A组肌肉注射速眠新(0.3 m L/kg),B组肌肉注射速眠新复合盐酸氯胺酮混合液(0.3 m L/kg),C组肌肉注射速眠新复合盐酸氯胺酮混合液(0.3 m L/kg),并静注地西泮注射液(1.5 m L/kg),对比三组的麻醉效果、麻醉显效时间、初次麻醉维持时间、总麻醉药用量及总手术时间。结果 C组麻醉显效时间明显短于A、B组(P0.01);初次麻醉维持时间C组长于A、B组(P0.01);总麻醉药用量C组明显少于A、B组(P0.01);C组总的手术时间少于A、B两组(P0.01);C组的麻醉效果优于A、B组(P0.01)。结论采用速眠新、盐酸氯胺酮联合地西泮复合麻醉明显提高了麻醉效果,是适于家兔敏感手术部位及手术时间较长的动物实验的理想麻醉方法。
[Abstract]:Objective to improve the deficiency of simplex and compound anesthesia methods and to observe the effect of diazepam on the anesthetic effect of Sumianxin combined with ketamine hydrochloride. Methods 80 adult rabbits, half male and half female, were randomly divided into two groups (A). Group B was injected intramuscularly with the mixture of new and ketamine hydrochloride (0.3 mL 路kg ~ (-1) 路kg ~ (-1)). Group C was given intramuscular injection of Sumianxin combined with ketamine hydrochloride (0.3 mL / kg) and intravenous injection of diazepam (1.5 mL / kg). The anesthetic effects of the three groups were compared. Results the effective time of anesthesia in group C was significantly shorter than that in group A (P 0.01). The maintenance time of primary anesthesia in group C was longer than that in group A (P 0.01). The dosage of total anesthetic in group C was significantly lower than that in group A (P 0.01). The total operative time in group C was less than that in group A and B (P 0.01). The anesthetic effect of group C was better than that of group A B (P 0.01). Conclusion the compound anesthesia of ketamine hydrochloride combined with diazepam can obviously improve the anesthetic effect. It is an ideal anesthetic method suitable for sensitive operation site and long operation time in rabbits.
【作者单位】：中国医学科学院北京协和医学院整形外科医院;
【分类号】：R614

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