不同BIS值对术后认知功能障碍的影响Meta分析

发布时间：2018-02-06 02:59

本文关键词： 麻醉深度术后认知功能障碍 Meta分析　出处：《临床麻醉学杂志》2015年08期 　论文类型：期刊论文

【摘要】：目的采用Meta分析方法比较不同BIS条件下对术后早期认知功能障碍(POCD)发生率的影响。方法检索PubMed、Embase、OVID、CBM、知网、万方、维普等数据库,时间从建库至2014年12月,收集相关不同麻醉深度对术后早期POCD发生率影响的文献,仔细阅读获取的文献摘要和全文,并对其参考文献进行追踪,对纳入的文献进行数据提取及质量评价,并采用RevMan 5.3软件进行Meta分析。结果共纳入6篇文献,包括521例患者。有4篇文献(255例患者)比较了深麻醉状态(BIS 30~40)与常规麻醉状态(BIS 40~60)术后早期POCD的发生率,深麻醉状态可降低POCD发生率(OR=0.40,95%CI 0.22~0.73,P=0.002)。有3篇文献(216例患者)比较了常规麻醉状态下BIS 40~50与BIS 50~60术后早期POCD的发生率,BIS 40~50并不明显降低POCD发生率(OR=1.11,95%CI 0.24~5.24,P=0.9)。结论深麻醉状态比常规麻醉状态下POCD发生率低,但由于随机对照试验的数量及质量不足,上述结论尚需开展更大样本及严谨设计的随机对照试验加以论证。
[Abstract]:The purpose of using the Meta analysis method on early postoperative cognitive dysfunction under different BIS conditions (POCD). The incidence of Embase, OVID retrieval method PubMed, CBM, CNKI, Wanfang, VIP database, time from inception to December 2014, collected in different depth of anesthesia on early postoperative POCD incidence of the literature reading, the literature summary and the full text carefully, and the reference track of data extraction and quality assessment of included studies, and Meta analysis was performed using RevMan 5.3 software. Results a total of 6 studies, including 521 patients. There were 4 literatures (255 patients) compared with deep anesthesia (BIS 30~40) and general anesthesia (BIS 40~60) after operation, the incidence of early POCD deep anesthesia can reduce the incidence of POCD (OR=0.40,95%CI, 0.22~0.73, P=0.002). There are 3 articles (216 patients) compared with conventional anesthesia. The incidence of early POCD BIS 40~50 and BIS 50~60 after operation, BIS 40~50 does not significantly reduce the incidence of POCD (OR=1.11,95%CI, 0.24~5.24, P=0.9). Conclusion deep anesthesia with low incidence of anesthesia than conventional POCD, but because of the number and quality of randomized controlled trials, the conclusion still needs more large sample and rigorous design of randomized controlled trials to demonstrate.

【作者单位】：广州医科大学附属第三医院;广州医科大学附属第三医院麻醉科;广州医科大学附属第三医院心内科;
【分类号】：R614

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