老年胃肠道肿瘤患者术中输注氨基酸对术后肝肾功能的影响

发布时间：2018-03-04 10:34

  本文选题：老年患者　切入点：氨基酸　出处：《中国癌症杂志》2015年08期 　论文类型：期刊论文

【摘要】：背景与目的:以往研究显示,术中输注氨基酸可以缓解核心体温的降低。该研究旨在探讨术中输注氨基酸对硬膜外阻滞复合全麻下行胃肠道肿瘤手术老年患者术后肝肾功能的影响。方法:选择在硬膜外阻滞复合全麻下行胃肠道肿瘤手术的65~75岁患者40例,ASAⅠ~Ⅱ级,按随机数字表法随机分为2组:氨基酸干预组和0.9%氯化钠溶液组,各20例。分别在麻醉诱导同时输注11.4%复方氨基酸注射液2 m L·(kg·h)-1和0.9%氯化钠注射液2 m L·(kg·h)-1直至手术结束。记录诱导即刻、手术开始后90 min、关腹时鼻咽温度;查术前、术后第1天、术后第1周的肝肾功能指标:总胆红素(TBIL)、结合胆红素(DBIL)、总蛋白(TP)、白蛋白(ALB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素(BUN)、肌酐(Scr)、尿酸(UA)。结果:手术开始后90 min及关腹即刻,氨基酸干预组鼻咽温度均高于0.9%氯化钠溶液组,两组比较差异有统计学意义(P0.05)。两组各时间点肝肾功能指标均在正常范围内。两组组内比较,TBIL、DBIL在术后第1天均较术前升高(P0.05),但显著低于术后第1周(P0.05);TP、ALB在术后第1天、术后第1周均较术前降低(P0.05);ALT、AST在术后第1天、术后第1周较术前升高(P0.05);BUN在术后第1天较术前降低(P0.05);术后第1周Scr、UA较术前及术后第1天降低(P0.05);UA在术后第1天较术前降低(P0.05)。但两组间比较,差异均无统计学意义(P0.05)。结论:胃肠道肿瘤手术对老年患者术后肝肾功能有所影响,而术中输注氨基酸在改善麻醉手术引起的低温的同时不影响术后肝肾功能。
[Abstract]:Background and objective: Previous studies have demonstrated that intraoperative amino acid administration can alleviate transmission reduce the core body temperature. This study aimed to investigate the effects of amino acid infusion epidural anesthesia anesthesia on the gastrointestinal cancer surgery in elderly patients with postoperative liver and renal function during the operation. Methods: 40 patients aged 65~75 in epidural anesthesia combined with general anesthesia gastrointestinal cancer surgery patients, ASA grade I-II, were randomly divided into 2 groups: the intervention group and Sodium Chloride Solution group of 0.9% amino acids, respectively. All 20 cases in the induction of anesthesia while infusion of 11.4% Compound Amino Acid Injection 2 m L (kg h -1) and 0.9% L (kg - m Sodium Chloride Injection 2 h) over -1 until operation. Record the induction immediately after the start of surgery 90 min, abdominal closure nasopharyngeal temperature; preoperative check, first days after surgery, liver and kidney function first weeks after surgery: total bilirubin (TBIL), total bilirubin (DBIL), total protein (TP), egg white 鐧，

本文编号：1565331